Assessing the effectiveness of mouthwashes against SARS-CoV-2 before dental procedures

Investigating the effectiveness of oral antiseptic rinses on SARS-CoV-2 in-vivo - a randomised controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN16269648

Enrollment

Registered

2021-06-24

Start date

2021-06-28

Completion date

Unknown

Last updated

2024-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19 (SARS-CoV-2 infection) Infections and Infestations

Interventions

Participants with a positive COVID test within the last 72 hours will be randomised to four types of mouthwash by a random number generator. The mouthwashes to be tested are as follows: 1. Orawise+ (h

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Participants aged over 16 years with a positive COVID-19 swab test in the last 72 hours 2. Participants will only be recruited if they are well enough, i.e. only showing mild to moderate symptoms/signs of COVID-19 infection

Exclusion criteria

Exclusion criteria: 1. Refusal of consent 2. Participants known to be pregnant 3. Participants who have allergies to any of the mouthwashes used in the trial

Design outcomes

Primary

Measure	Time frame
Levels of SARS-CoV-2 in saliva samples measured quantitatively by determining the 50% tissue culture infectious dose (TCID50) and the infectious virus titre in TCID50/ml, at baseline (pre-mouth washing) and 1, 10, 30 and 60 minutes after mouth washing	—

Secondary

Measure	Time frame
There are no secondary outcome measures	—

Countries

England, United Kingdom

Contacts

Public ContactMia Porteous

mia.porteous@york.nhs.uk+44 (0)1904 725129

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026