Treatment of increased gut permeability (so called leaky gut syndrome) and food intolerance in non-elite endurance athletes Digestive System
Conditions
Interventions
Randomisation will be performed in Excel using the following function: =rand(): assign random numbers to each observation. Athletes with leaky gut syndrome and/or probable food allergy/intolerance dia
Sponsors
The Jerzy Kukuczka Academy of Physical Education
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Endurance athletes who have been training an endurance event, such as running, cycling, triathlon or swimming for at least 2 years and for a minimum of 4 hours a week 2. A good state of health confirmed by a medical doctor or an ECG and blood test
Exclusion criteria
Exclusion criteria: 1. Exclusion criteria: 1.1. Health contraindications to performing an exercise test confirmed by a medical doctor or blood test and ECG results 1.2. No informed consent to participate in the study 2. Specific exclusion criteria: 2.1. Skin prick test: 2.1.1. Severe eczema 2.1.2. Pregnancy 2.2. Prior to performing an exercise test: 2.2.1. Feeling unwell 2.2.2. Shortness of breath, nausea, dizziness or pain during exercise testing
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Leaky gut syndrome is measured using the serum level of intestinal fatty acid binding protein (I-FABP), interleukin 6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha), and a screening interview at baseline 2. Probiotics supplementation effect is measured by potential changes in the serum level of intestinal fatty acid binding protein (I-FABP), interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha), and a screening interview at 8 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Probable food allergy is measured by assessing the levels of serum-specific immunoglobulins (IgE >=0.35 kU/ml), skin prick test (wheal size >=3 mm/3 mm and a validated questionnaire PAFA/EuroPrevall before supplementation at baseline 2. Food intolerance is measured by assessing the levels of serum-specific immunoglobulins (IgE <0,35 kU/mL), skin prick test (wheal size < 3mm/3mm and a validated questionnaire PAFA /EuroPrevall at baseline 3. Level of aerobic fitness determined by maximum oxygen uptake achieved during a graded exercise test on a treadmill or a cycle-ergometer at baseline and 8 weeks | — |
Countries
Poland
Contacts
Public ContactBarbara Hall
Outcome results
None listed