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Control of sand fleas in the soil using insect growth regulators

Testing insect-growth regulators to control off-host stages of Tunga penetrans

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN16207849
Enrollment
105
Registered
2025-06-23
Start date
2022-10-24
Completion date
Unknown
Last updated
2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tungiasis Infections and Infestations

Interventions

A household randomized controlled study with three arms: 1. Water-based emulsified pyriproxyfen solution (0.06 ppm) 2. Water only 3. No treatment at all The households enrolled on arms 1 and 2 had t

Sponsors

International Centre of Insect Physiology and Ecology
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Households with a natural earthen floor 2. Total floor area of households less than 72 square meters. A maximum size limit was set to limit the amount of product that needed to be prepared 3. Households with at least two members with more than 5 embedded fleas 4. The head of the household provided signed consent to participate

Exclusion criteria

Exclusion criteria: Households that were in very poor condition and considered likely to collapse within the timeframe of the study

Design outcomes

Primary

MeasureTime frame
Proportion of households containing off-host stages of the sand flea Tunga penetrans measured using count data of the flea larvae extracted in the laboratory at baseline and week 5

Secondary

MeasureTime frame
1. The flea abundance (number of larvae per unit of soil) measured using count data of the flea larvae extracted in the laboratory at baseline and week 5 2. Any potential change of tungiasis infection in household members measured using a comparison of standard rapid assessments of feet at baseline and end-line

Countries

Kenya

Contacts

Public ContactUlrike Fillinger
ufillinger@gmail.com+254791845259

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026