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Evaluation of the use of the local anaesthetic drug lidocaine to decrease pain and opioid doses in burned patient when given as intravenous infusion

Effect of intravenous infusion of Xylocard on morphine consumption among patients with burns > 10% TBSA

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN16172216
Enrollment
25
Registered
2018-01-08
Start date
2005-07-11
Completion date
Unknown
Last updated
2018-02-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain in burned patients Injury, Occupational Diseases, Poisoning Pain in burned patients

Interventions

Participants are randomly allocated to one of two groups: the intervention group or the control group. Interventional drug: intravenous infusion of lidocaine starting with bolus dose 1 mg/kg, follow

Sponsors

Linkoping University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Burns more than 10 Total body surface area (tbsa) 2. Aged between 18 and 70 years 3. Adminstration of patient controlled anaglesia (morphine);Inclusion criteria: 1. Burns more than 10 Total body surface area (tbsa) 2. Aged between 18 and 70 years 3. Adminstration of patient controlled anaglesia (morphine)

Exclusion criteria

Exclusion criteria: 1. Untreated AV-block type II or III 2. Known heart failure 3. Known allergy to local anaesthesia 4. Liver cirrhosis and severe renal dysfunction ;Exclusion criteria: 1. Untreated AV-block type II or III 2. Known heart failure 3. Known allergy to local anaesthesia 4. Liver cirrhosis and severe renal dysfunction

Design outcomes

Primary

MeasureTime frame
Opioid consumption (intravenous and oral in milligram/day) is measured using the recordings from both infusion pump and nurses’ written doses administered at baseline day 0, days 1-3 and days 4-6.;Opioid consumption (intravenous and oral in milligram/day) is measured using the recordings from both infusion pump and nurses’ written doses administered at baseline day 0, days 1-3 and days 4-6.

Secondary

MeasureTime frame
Pain is measured using the visual analogue scale (measured six times per day) at baseline day 0, days 1-3 and days 4-6.;Pain is measured using the visual analogue scale (measured six times per day) at baseline day 0, days 1-3 and days 4-6.

Countries

Sweden

Contacts

Public ContactFolke;Folke Sjoberg;Sjoberg

;

folke.sjoberg@liu.se;folke.sjoberg@liu.se+46 (0)101 031820;+46 (0)101 031820

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026