Nasal polyps Ear, Nose and Throat
Conditions
Interventions
Patients undergoing resection of nasal polyps and/or turbinates for clinical reasons by ENT surgeons at NHS research sites will be invited by their clinical care teams to consider donating resected na
the reasons for the nasal surgery
any relevant medications the participant is taking
and any previous immunology test results. The patients age, gender, ethnicity and BMI will also be recorded. When these questions are not clearly answered in the medical notes, the patient will be ask
Sponsors
Queen Mary University of London
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients undergoing resection of nasal tissue for clinical indications (e.g. polypectomy, turbinectomy, septoplasty, tonsilectomy) 2. Able to give consent 3. Aged 18 years and over The researchers will specifically recruit the following subgroups: 1. Patients undergoing nasal polyp resections, who are not on biologics 2. Patients undergoing nasal polyp resections, who are on anti-IL-5 biologics 3. Patients undergoing nasal operations other than polyp resection
Exclusion criteria
Exclusion criteria: 1. Inability to give consent 2. Previous rituximab treatment (ever) 3. Chemotherapy with preceding 6 months 4. Cystic fibrosis 5. Pregnancy or breastfeeding 6. Known current COVID infection/TB infection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The B cell receptor (BCR) (antibody immunoglobulin) repertoire of tissue-resident airway B-cells, in particular the relative expression of different immunoglobulin classes and subclasses. Measured using single-cell and bulk RNA sequencing at baseline. | — |
Secondary
| Measure | Time frame |
|---|---|
| BCR repertoires for convergent clonotypes evident in blood (from IDEA project) and other available BCR libraries, to assess for potential pathological clonotypes in eosinophilic airway inflammation. Measured using single-cell and bulk RNA sequencing at baseline. | — |
Countries
England, United Kingdom
Outcome results
None listed