Glucose and ketone bodies metabolism Not Applicable
Conditions
Interventions
Ten healthy participants will be asked to fast for 24 hours before their visit. On their visit to the Department of Physiology and Genetics of the University of Oxford, they will be asked to consume a
Sponsors
TdeltaS Ltd
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Participants must be fluent in English, have no communication impairments and should be willing and able to give informed consent for participation in the trial 2. Aged 18 – 70 (inclusive) 3. With no known medical diagnosis 4. Have had no course of medication, whether prescribed or over-the-counter, in the four weeks before the first trial dose and no individual doses in the final two weeks other than over the counter analgesics, vitamins and mineral supplements or, for females, oral contraceptives 5. Female participants of childbearing potential and male participants whose partner is of childbearing potential must be willing to ensure that they or their partner mechanical or pharmacological contraception during the trial and for 3 months thereafter 6. In the Investigator’s opinion, is able and willing to comply with all trial requirements 7. Willing to allow his or her General Practitioner and consultant, if appropriate, to be notified of participation in the trial
Exclusion criteria
Exclusion criteria: 1. Female participant who is pregnant, lactating or planning pregnancy during the trial 2. Significant renal or hepatic impairment 3. Scheduled elective procedures requiring general anaesthesia during the trial 4. Any other significant disease or disorder which, in the opinion of the investigator, may either put the participants at risk because of participation in the trial, or may influence the result of the trial, or the participant’s ability to participate in the trial 5. Participants who have participated in another research trial involving an investigational product in the past 12 weeks
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood glucose levels, measured using blood samples collected through a venous cannula at baseline and every 15 minutes during two hours | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood alanine and fatty acid levels, measured using blood samples collected through a venous cannula at baseline and every 15 minutes during two hours | — |
Countries
England, United Kingdom
Contacts
Public ContactLuis Adrian Soto Mota
Outcome results
None listed