HEpatic Resection Analgesia and Length of time to Discharge

Short-term outcomes with intrathecal opioid and patient controlled analgesia versus thoracic epidural analgesia for hepatic resection: a randomised controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN16147723

Enrollment

Registered

2015-01-28

Start date

2014-12-01

Completion date

Unknown

Last updated

2021-05-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatic resection Surgery

Interventions

Patients will be randomised to either thoracic epidural analgesia or intrathecal diamorphine with Fentanyl PCA.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Consent for enrolment 2. Patients presenting for elective one-stage open Hepatic Resection surgery at the Royal Free Hospital, London 3. Patients receiving a midline +/- a transverse incision in the right upper quadrant (‘reverse L incision’) 4. No contraindication to, or refusal to receive, central neuraxial block (epidural or spinal analgesia) 5. Aged at least 16

Exclusion criteria

Exclusion criteria: 1. Adult unable to give informed consent 2. Allergy to local anaesthetics 3. Infection around the potential puncture site 4. Coagulation disorders (INR >1.5, platelets <100 x 10(9)) 5. Chronic pain, requiring opioid analgesia or illicit opioid use 6. Mobility problems requiring assistance

Design outcomes

Primary

Measure	Time frame
Length of stay until medically fit for discharge; Timepoint(s): Time until medically fit for discharge post operatively	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026