Decompensated liver cirrhosis Digestive System Chronic Liver Disease/Cirrhosis
Conditions
Interventions
1. 50-100 mL of bone marrow was aspirated from the anterior iliac crest under local anesthesia
2. At least 100 million of enriched mononuclear cells was infused into the hepatic artery of the patient
Sponsors
N. Kipshidze Central University Hospital (Georgia)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Chronic hepatic failure 2. Ultrasonographic evidences of cirrhosis and portal hypertension 3. Child-Pough class B and C score 4. Patients must have the ability to sign the informed consent
Exclusion criteria
Exclusion criteria: 1. Patients aged less than 18 or more than 70 2. Hepatopulmonary syndrome 3. Documented hepatocellular carcinoma or history of other cancer 4. Presence of hepatic, portal or splenic vein thrombosis on doppler ultrasonography 5. History of autoimmune diseases 6. Use of hepatotoxic drugs within the last 6 month before enrolment 7. Decompensated heart failure 8. Renal failure (creatinine >2.5 mg/dL) 9. International normalized ratio (INR) >2.2 10. Patients with acute infection 11. Patients with pregnancy or lactation 12. Patients with recurrent gastrointestinal bleeding 13. Patients with spontaneous bacterial peritonitis 14. Patients unable to give informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Liver function (blood) test 2. Model for End-Stage Liver Disease (MELD) score 3. Child-Pugh Score for cirrhosis mortality | — |
Secondary
| Measure | Time frame |
|---|---|
| Cirrhosis mortality | — |
Countries
Georgia
Outcome results
None listed