Prediction of acute kidney injury after cardiac surgery

Conditions

Acute kidney injury after cardiac surgery Surgery Acute kidney injury after cardiac surgery

Husain-Syed F, Ferrari F, Sharma A, Hinna Danesi T, Bezerra P, Lopez-Giacoman S, Samoni S, de Cal M, Corradi V, Virzì GM, De Rosa S, Muciño Bermejo MJ, Estremadoyro C, Villa G, Zaragoza JJ, Caprara C, Brocca A, Birk HW, Walmrath HD, Seeger W, Nalesso F, Zanella M, Brendolan A, Giavarina D, Salvador L, Bellomo R, Rosner MH, Kellum JA, Ronco C.

2019-02-0168 citations

10.1093/ndt/gfy227

Preoperative Renal Functional Reserve Predicts Risk of Acute Kidney Injury After Cardiac Operation.

Husain-Syed F, Ferrari F, Sharma A, Danesi TH, Bezerra P, Lopez-Giacoman S, Samoni S, de Cal M, Corradi V, Virzì GM, De Rosa S, Muciño Bermejo MJ, Estremadoyro C, Villa G, Zaragoza JJ, Caprara C, Brocca A, Birk HW, Walmrath HD, Seeger W, Nalesso F, Zanella M, Brendolan A, Giavarina D, Salvador L, Bellomo R, Rosner MH, Kellum JA, Ronco C.

2018-01-3183 citations

10.1016/j.athoracsur.2017.12.034

Interventions

Participants with normal glomerular filtration rates who are undergoing an elective cardiac surgery are included in this study. Participants undergo a preoperative kidney stress test using high oral p

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Older than 18 years 2. Undergoing elective cardiac surgery 3. Signed informed consent forms

Exclusion criteria

Exclusion criteria: 1. Pregnancy 2. Chronic kidney disease = stage III 3. Solitary kidney 4. Diabetes mellitus type 1 5. Recent cardiac arrest 6. Liver failure or cirrhosis 7. Total parenteral nutrition 8. Hemoglobin <11 g/dl 9. Sepsis 10. History of malabsorption, chronic inflammatory bowel disease, short bowel, or pancreatic insufficiency 11. Transplant donor or recipient 12. Active autoimmune disease with renal involvement 13. Rhabdomyolysis 14. Prostate hypertrophy with International Prostate Symptom Score =20 15. Neoplasm

Design outcomes

Primary

Measure	Time frame
1. Renal functional reserve (RFR) is measured using a high oral protein load kidney stress test at baeline (before cardiac surgery) and three months after surgery 2. Acute kidney injury is measured using KDIGO criteria seven days after surgery	—

Secondary

Measure	Time frame
1. Occurrence of acute kidney injury impact the RFR is measured using Kidney Disease Improving Global Outcomes criteria at three months after surgery 2. Urinary biomarkers (TIMP-2 and IGFBP7) to predict loss of RFR are measured using urine samples at basline, 30 minutes after initiation of cardiopulmonary bypass, at intensive care unit admission, four, 12 and 24 hours after surgery and at hospital discharge	—

Measure

Time frame

1. Occurrence of acute kidney injury impact the RFR is measured using Kidney Disease Improving Global Outcomes criteria at three months after surgery 2. Urinary biomarkers (TIMP-2 and IGFBP7) to predict loss of RFR are measured using urine samples at basline, 30 minutes after initiation of cardiopulmonary bypass, at intensive care unit admission, four, 12 and 24 hours after surgery and at hospital discharge

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Countries

Italy

Outcome results

None listed