Retained placenta Pregnancy and Childbirth Retained placenta and membranes
Conditions
Interventions
Study medication will be randomised in blocks and the allocation of sealed envelopes will be in sequence of enrolment. Randomisation of misoprostol to placebo will be 2:1. 30 minutes after delivery of
Sponsors
Tanzanian German Programme to Support Health (TGPSH) (Tanzania)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Women with a retained placenta 30 minutes after delivery of the newborn (and a pregnancy duration of at least 28 weeks [birth weight 1 kg]). All women will receive active management of third stage of labour before inclusion.
Exclusion criteria
Exclusion criteria: 1. Blood loss greater than 750 ml 30 minutes after delivery 2. Pulse rate greater than 120 beats/minute 3. Blood pressure (BP) dropped greater than 20 mmHg diastolic compared with BP before delivery 4. Anaemia (haemoglobin [Hb] less than 100 g/dl). Measurement of third trimester of pregnancy or around delivery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction in the amount of manual removal of placenta (under anaesthesia) 60 minutes after delivery of the baby. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Blood loss 2. Need for blood transfusion Hb will be checked the morning after the manual removal or the sponteneous expulsion of the placenta. After this it will be decided if a blood transfusion is necessary. | — |
Countries
Tanzania
Outcome results
None listed