Sleep changes from exercise in chronic pain patients

Exercise improves sleep in chronic pain patients: A feasibility interventional study with ecological momentary assessment to capture long-term sleep patterns

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN16093248

Enrollment

Registered

2023-08-07

Start date

2021-02-02

Completion date

Unknown

Last updated

2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic temporomandibular pain disorder Nervous System Diseases

Interventions

Each day, participants in exercise group will complete the following: chin tucks 10x/hour holding for 5 seconds, 30-60 seconds of closure-muscle stretching exercise 6x/day, 15 seconds of chest stretch

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged 18 - 65 years 2. Can speak and write in English 3. Myogenous chronic non-neuropathic pain equal to at least 2 on a scale of 1-10 for orofacial pain 4. Pain duration longer than 3 months 5. Type of pain is in the jaw, temple, in ear, or in front of the ears 6. Pain is modified with jaw movement, function, or parafunction 7. Exam positive for confirmation of pain location(s) in the temporalis or masseter muscle(s) and reports familiar pain in the temporalis or masseter muscle(s) with at least one of the following provocation tests: Palpation of the temporalis or masseter muscle(s) or maximum unassisted or assisted opening movement(s).

Exclusion criteria

Exclusion criteria: 1. Aged over 65 years 2. History of local or general trauma, degenerative neuromuscular diseases, cervical pain (ie. stenosis, radiculopathy) 3. Removable full dental prostheses 4. Neuropathic temporomandibular pain 5. Major neurological or psychiatric disorders (ie. schizophrenia, bipolar disorders, autism).

Design outcomes

Primary

Measure	Time frame
1. Sleep quality is measured using Patient-Reported Outcomes Measurement Information System (PROMIS) sleep disturbances, and an actigraph watch continuously for the 4 weeks of the study. PROMIS-sleep disturbance is measured at baseline, week 1 to week 4. Actigraphy is obtained continuously over the 4 weeks. 2. Chronic pain related outcomes including chronic pain interference, pain behavior, depression and anxiety were assessed weekly using PROMIS pain interference, pain behavior, depression and anxiety scales. Pain related outcomes are measured at baseline, week 1 to week 4.	—

Measure

Time frame

1. Sleep quality is measured using Patient-Reported Outcomes Measurement Information System (PROMIS) sleep disturbances, and an actigraph watch continuously for the 4 weeks of the study. PROMIS-sleep disturbance is measured at baseline, week 1 to week 4. Actigraphy is obtained continuously over the 4 weeks. 2. Chronic pain related outcomes including chronic pain interference, pain behavior, depression and anxiety were assessed weekly using PROMIS pain interference, pain behavior, depression and anxiety scales. Pain related outcomes are measured at baseline, week 1 to week 4.

—

Secondary

Measure	Time frame
Peripheral blood mononuclear cells RNA changes. Peripheral blood is withdrawn at the baseline enrollment visit and at the end of the intervention period for both exercise and no exercise groups.	—

Countries

United States of America

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026