Exercise and non-alcoholic steatohepatitis

The effect of exercise on active liver injury, inflammation and liver lipid in people with non-alcoholic steatohepatitis

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN16070927

Enrollment

Registered

2015-01-09

Start date

2013-03-01

Completion date

Unknown

Last updated

2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Topic: Metabolic and endocrine disorders, Hepatology

Interventions

Participants will undergo five metabolic assessment visits to the research facility, interspersed by either 12 weeks of supervised exercise therapy or continue their normal care.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. NASH confirmed by liver biopsy; this is the study group 2. Sedentary; we are looking at the effect of increased exercise 3. The person's weight needs to be stable as we are interested in the independent effect of exercise 4. Aged 18 years and over 5. Understanding of English (as without this supervised gym visits will not be possible)

Exclusion criteria

Exclusion criteria: 1. NASH confirmed by liver biopsy; this is the study group 2. Sedentary; we are looking at the effect of increased exercise 3. The person's weight needs to be stable as we are interested in the independent effect of exercise 4. Aged 18 years and over 5. Understanding of English (as without this supervised gym visits will not be possible)

Design outcomes

Primary

Measure	Time frame
Liver lipids, abdominal fat content, insulin sensitivity; Timepoint(s): 12 weeks	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 1, 2026