Comparison of magnesium given by mouth to magnesium given through the vein to treat patients with low blood magnesium

Comparison of oral and intravenous magnesium repletion in patients with hypomagnesemia: a randomized controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN16067597

Enrollment

120

Registered

2022-08-25

Start date

2015-07-10

Completion date

Unknown

Last updated

2022-09-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypomagnesemia Nutritional, Metabolic, Endocrine

Interventions

Participants will be randomized into three groups. The randomization process will involve randomly generated numbers placed in sealed envelopes. Group 1 received magnesium oxide (MgOx) 400 mg tabs: 16

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Inpatient at the participating medical center 2. Aged >18 years 3. Serum magnesium between 1.2 and 1.7 mg/dl

Exclusion criteria

Exclusion criteria: 1. Proton pump inhibitor (PPI) use 2. Concomitant diuretic use 3. Acute or chronic renal insufficiency 4. Active myocardial infarction 5. Eclampsia or preeclampsia 6. Pregnancy 7. Incarcerated status 8. Unable to tolerate oral intake 9. History of bowel surgery 10. Active diarrhea 11. Concomitant chemotherapy 12. Severe sepsis 13. Prior enrollment in the study

Design outcomes

Primary

Measure	Time frame
Absolute serum magnesium level measured from blood samples collected at the time of enrollment and between 18 and 30 h after initiation of repletion	—

Secondary

Measure	Time frame
The relative rise in serum magnesium level measured from blood samples collected at the time of enrollment and between 18 and 30 h after initiation of repletion	—

Countries

United States of America

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026