Atherosclerosis Circulatory System
Conditions
Interventions
This is a crossover study. Participants will be randomized using computer software to determine whether they consume red wine or cachaça in the first intervention period. Each participant will start
Sponsors
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged over 18 years 2. Able to drink alcohol 3. Able to abstain from alcohol for 1 week
Exclusion criteria
Exclusion criteria: 1. Established cardiovascular disease, defined as documented atherosclerosis, previous cardiovascular event, myocardial revascularization, heart failure 2. Chronic use of corticosteroids, non-anti-inflammatory steroidal drugs (NSAIDs), statins, oral hypoglycemic agents, insulins, anticoagulants or antiplatelet agents 3. Inability to sign the free and informed consent form 4. History of alcoholism or inability to remain abstinent for the period established in the study 5. Refusal to drink alcohol for the period established 6. Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| C-reactive Protein (CRP) level in blood at days 7, 35, 42 and 70 | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Ultrasensitive Troponin level in blood at days 7, 35, 42 and 70 2. Interleukin 10 (IL-10) level in blood at days 7, 35, 42 and 70 3. Interleukin 6 (IL-6) level in blood at days 7, 35, 42 and 70 4. Apolipoprotein A1 (ApoA1) level in blood at days 7, 35, 42 and 70 5. Apolipoprotein B (ApoB) level in blood at days 7, 35, 42 and 70 6. Fasting glucose level in blood at days 7, 35, 42 and 70 7. Insulin level in blood at days 7, 35, 42 and 70 8. Fibrinogen level in blood at days 7, 35, 42 and 70 9. Total cholesterol and fractions levels in blood at days 7, 35, 42 and 70 10. Platelet aggregability test level using blood taken at days 7, 35, 42 and 70 | — |
Countries
Brazil
Contacts
Public ContactPedro Cellia
Outcome results
None listed