Skip to content

Use of prednisone for choroidal detachment after trabeculectomy

Use of prednisone for choroidal detachment after trabeculectomy: a double-masked randomised controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN15966680
Enrollment
40
Registered
2008-10-30
Start date
2003-02-01
Completion date
Unknown
Last updated
2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Choroidal detachment after trabeculectomy Eye Diseases Other disorders of choroid

Interventions

Oral prednisone 1 mg/kg daily for 7 days followed by a progressive reduction of 10 mg every 7 days. Patients in the placebo group received similar capsules containing starch for the same duration as t

Sponsors

Coordination of Improvement of Higher Education (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior [CAPES]) (Brazil)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Both males and females, older then 18 years old 2. Primary open or narrow angle glaucoma submitted to trabeculectomy that developed choroidal detachment 3. Choroidal detachment should be diagnosed during the first two weeks after surgery 4. Choroidal detachment should be exudative by ultra-sound

Exclusion criteria

Exclusion criteria: 1. Other acute ocular disease 2. Positive Seidel test 3. Choroidal kissing 4. Athalamia 5. Clinical uncontrolled diabetes mellitus or systemic arterial hypertension 6. Hypersensitivity for any of the drugs components on the trial 7. Psychiatric disease 8. Pregnancy

Design outcomes

Primary

MeasureTime frame
Choroidal detachment resolution. Indirect ophthalmoscopy and ocular ultrasonography (B-mode) were performed weekly to evaluate the choroidal detachment until total reattachment of the choroid. The main outcome measure was the time elapsed between the detection of detachment and total reattachment of the choroid.

Secondary

MeasureTime frame
Intra-ocular pressure, evaluated every 5 days.

Countries

Brazil

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026