Changes in coagulation during induction of anesthesia in elective surgery: cholecystectomy Surgery
Conditions
Interventions
40 patients subjected to cholecystectomy during general anesthesia are asked to participate in the study, during preanesthetic evaluation. 40 envelopes are placed in a box. The envelope picked decides
Sponsors
Linköping University Hospital (Sweden)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients over the age of 18, belonging to American Society of Anaesthesiologists (ASA) physical status classification score groups I and II 2. Patients operated with cholecystectomy 3. Patients signing informed consent after oral and written information
Exclusion criteria
Exclusion criteria: 1. Regional anesthesia 2. Age less than 18 years 3. Pregnancy 4. ASA group III and IV 5. Cardiac disease 6. Known kidney failure (creatinine >170) 7. Rheumatoid arthritis 8. Treatment with anticoagulants
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Qualitative analysis of blood clotting by rotational trombelastometry (ROTEM). Blood samples are collected prior to anesthesia and 15 minutes after induction of anesthesia. | — |
Secondary
| Measure | Time frame |
|---|---|
| All other clotting tests performed before and 15 minutes after induction of anesthesia: 1. Hemoglobin (Hgb) 2. Albumin 3. Thrombin antthrombin complex (TAT) 4. D-dimer 5. Soluble P-selectin 6. Activated partial thrombin time (APTT) 7. Prothrombin time (PT) and international normalized ratio (INR) 8. Platelets | — |
Countries
Sweden
Outcome results
None listed