A comparative study between the antifungal activity of curcumin and nystatin in denture stomatitis (randomized controlled trial)

In patients with denture stomatitis, is there evidence to suggest that curcumin gives better clinical and laboratory antifungal results than nystatin?

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN15898291

Enrollment

Registered

2023-08-24

Start date

2022-10-03

Completion date

Unknown

Last updated

2026-05-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Denture stomatitis Oral Health

Interventions

Patients who are informally and clinically positive for denture stomatitis will be enrolled in this study. The patients were divided into two groups: Group I: Curcumin suspension three times a day,

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Adult patients 2. Male or female 3. Who use dental devices 4. Clinically and informally diagnosed with denture stomatitis

Exclusion criteria

Exclusion criteria: 1. Pregnant or nursing women 2. Patients treated with any antifungal medication over the past two weeks 3. Patients with any allergic reactions to studied substances 4. Patients with HIV 5. Immunosuppressed patients

Design outcomes

Primary

Measure	Time frame
1. Healing measured using a scale of oral mucositis at 7 and 14 days 2. Taste acceptability measured using a Hedonic scale on the day 14 since treatment began	—

Secondary

Measure	Time frame
Laboratory assessment measured using the decrease in the number of fungal colonies taken before the commencement of processing and on day 14 after the completion of processing	—

Countries

Syria

Contacts

Public ContactAbeer Aljoujou

abeerjoujou@gmail.com+963944703131

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: May 7, 2026