Adherence to Mediterranean diet can reduce the risk of obesity in people with genetic predisposition to obesity

Mediterranean dietary pattern adherence modify the association between FTO genetic variations and obesity phenotypes

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN15898185

Enrollment

1254

Registered

2017-08-02

Start date

1999-01-31

Completion date

Unknown

Last updated

2023-10-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity Nutritional, Metabolic, Endocrine Obesity

Interventions

Participants undergo a baseline survey. Those who are evaluated as obese are excluded. The other participants are followed and randomly selected for follow-up surveys between 2006-2008, 2008-2011 and

dietary ratio of monounsaturated fatty acid (MUFA) to saturated fatty acid (SFA)

intake of dairy products, mostly in the form of cheese or yogurt and intakes of meat and poultry. The anthropometric, physical activity, smoking and the other demographic variables are assessed at bas

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Age =18 years 2. Both genders 3. Participating in baseline and follow-up examinations of Tehran Lipid and Glucose Study 4. BMI=30 for cases, BMI=18.5 and 5 kg in the last 6 months 7. Not taking drugs that affect weight 8. Not under or over-reporters of energy intake 9. DNA purification in the range of 1.7<A260/A280<2

Exclusion criteria

Exclusion criteria: 1. Individuals with a history of weight loss or gain >5 kg in the last 6 months 2. Pregnant and lactating 3. Taken drugs that affect weight 4. Cases/controls lacking DNA purification in the range of 1.7<A260/A280<2 5. Reported energy intakes divided by the predicted energy intake did not qualify for the ±3SD range

Design outcomes

Primary

Measure	Time frame
1. Weight is measured using the digital scales at baseline and each follow-up examination (every three years) 2. Height is measured using a tape measure at baseline and each follow-up examination (every three years) 3. Waist circumference is measured using the upstretched tape meter at baseline and each follow-up examination (every three years) 4. Hip circumference is measured using the upstretched tape meter at baseline and each follow-up examination (every three years)	—

Measure

Time frame

1. Weight is measured using the digital scales at baseline and each follow-up examination (every three years) 2. Height is measured using a tape measure at baseline and each follow-up examination (every three years) 3. Waist circumference is measured using the upstretched tape meter at baseline and each follow-up examination (every three years) 4. Hip circumference is measured using the upstretched tape meter at baseline and each follow-up examination (every three years)

—

Secondary

Measure	Time frame
1. BMI (body mass index) is calculated by dividing weight in kilograms on height in meters squared baseline (kg/m2) at baseline and each follow-up examination (every three years) 2. WHR (waist to hip ratio) is calculated by dividing waist on hip circumferences at baseline and each follow-up examination (every three years) 3. Obesity was defined as a BMI =30 kg/m2 4. BMI between 18.5 and 24.9 classified a person as having a normal weight 5. Waist circumference >95 cm for both genders was considered as indicators of abdominal obesity 6. WHR >0.8 in men and >0.9 in women, was considered as indicators of abdominal obesity	—

Measure

Time frame

1. BMI (body mass index) is calculated by dividing weight in kilograms on height in meters squared baseline (kg/m2) at baseline and each follow-up examination (every three years) 2. WHR (waist to hip ratio) is calculated by dividing waist on hip circumferences at baseline and each follow-up examination (every three years) 3. Obesity was defined as a BMI =30 kg/m2 4. BMI between 18.5 and 24.9 classified a person as having a normal weight 5. Waist circumference >95 cm for both genders was considered as indicators of abdominal obesity 6. WHR >0.8 in men and >0.9 in women, was considered as indicators of abdominal obesity

—

Countries

Iran

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026