Diagnosis of patients with exudative pleural effusion Respiratory
Conditions
Interventions
PROSPECT-PLEURA is a single-site, prospective observational diagnostic test accuracy study. There is no randomisation, no control arm, and no intervention
participants receive standard NHS clinical care throughout.
Participants
Adult NHS patients who are undergoing medically necessary pleural fluid sampling for a suspected or known exudative pleural ef
cell pellets are fixed or otherwise preserved for analysis. Some unfixed samples are cultured in containment level 2 facilities for short-term experimental use
no in vitro cell lines are established.
Scientific analyses include:
- Single-cell RNA sequencing of cellular conten
Sponsors
Lancaster University
Eligibility
Sex/Gender
All
Age
18 Years to 120 Years
Inclusion criteria
Inclusion criteria: 1. Undergoing medically necessary pleural fluid sampling or removal, via any method 2. The pleural effusion is suspected or known to be exudative 2. Aged 18 years or older and has capacity to consent to participate
Exclusion criteria
Exclusion criteria: 1. Latent, active, or suspected tuberculosis, whether pulmonary or extra-pulmonary 2. Clinically unstable patients requiring emergency removal of pleural fluid 3. Previous pleurodesis 4. Participating in ongoing PROSPECT-PLEURA patient and public involvement
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| A final clinical diagnosis, cytology report(s) and biomarker analyses measured using the diagnosis for the formation of a pleural effusion, as determined by the clinical care team. Final diagnosis can be made posthumously. at 3 years | — |
Countries
England, United Kingdom
Contacts
Public ContactOliver Mann
Outcome results
None listed