Myocardial Infarction with Obstructive Coronary Arteries (MINOCA) Circulatory System
Conditions
Interventions
Patients undergo sequential echo, cardiac and brain MRI scanning, blood tests and psychological testing as an inpatient at 6 weeks and at 6 months. The trialists will look for changes in clinician’s d
Sponsors
University of Bristol
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Current participant inclusion criteria as of 10/02/2020: 1. Aged 18 to 80 years 2. Meets the ESC universal definition of myocardial infarction 3. <50% epicardial coronary artery stenosis on invasive or CT coronary angiography in any potential infarct-related territory 4. No other clinically overt specific cause for the acute presentation at the time of angiography 5. Written informed consent Previous participant inclusion criteria: 1. Age 18-75 years 2. They meet the ESC universal definition of myocardial infarction 3. <50% epicardial coronary artery stenosis on invasive or CT coronary angiography in any potential infarct related territory 4. No other clinically overt specific cause for the acute presentation at the time of angiography 5. Written informed consent
Exclusion criteria
Exclusion criteria: Current participant exclusion criteria as of 10/02/2020: 1. Invasive or CT coronary angiography not performed or not diagnostic 2. Contraindications to MRI 3. Pregnant or breastfeeding 4. Prisoners 5. Unable to meet the follow-up requirements. 6. Timing of the initial CMR of >2 weeks after presentation 7. Previous CABG (coronary artery bypass graft) Previous participant exclusion criteria: 1. Invasive or CT coronary angiography not performed or not diagnostic 2. Contraindications to MRI 3. Pregnancy or breastfeeding 4. Prisoners 5. Patients unable to meet the follow up requirements. 6. Timing of the initial CMR of >2 weeks after presentation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in clinical diagnosis or change in clinical management measured via questionnaire at baseline | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. CMR mechanistics (LV function/volumes, presence and amount of oedema, native T1/T2 values, speckle tracking values, late gadolinium presence and pattern) measured at baseline, 6 weeks and 6 months 2. Differences in structural or resting functional brain MRI parameters in MINOCA patients compared to controls, measured at baseline and 6 months 3. All-cause mortality, cardiovascular readmissions (myocardial infarction, angina, heart failure, stroke), measured at 12 months | — |
Countries
United Kingdom
Outcome results
None listed