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Determinants of the onset and progression of diabetic retinopathy in south China: Guangzhou Diabetic Eye Study

Guangzhou Diabetic Eye Study (GDES): exploring the onset and progression of diabetic retinopathy and the determinants in south China: a prospective cohort study

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ISRCTN
Registry ID
ISRCTN15853192
Enrollment
1185
Registered
2020-04-13
Start date
2017-11-01
Completion date
Unknown
Last updated
2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetic retinopathy screening among people with diabetes Eye Diseases Diabetic retinopathy

Interventions

The GDES is an ongoing community-based prospective cohort study that includes type 2 diabetic patients registered in the community health centres in Yuexiu district in Guangzhou. This district is one

Sponsors

Sun Yat-sen University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Aged 35–85 years 2. Diagnosed type 2 diabetes confirmed by medical records from endocrinologists, insulin treatments, oral medicine, fasting blood glucose =7.0 mmol/L for at least two consecutive measurements or postprandial blood glucose =11.1 mmol/L 3. Ocular-treatment-naïve eyes

Exclusion criteria

Exclusion criteria: 1. Any severe systemic disease, such as ischemic heart disease, stroke, cancer and kidney disease, or a history of systemic surgery, such as cardiac bypass, thrombolysis and kidney transplantation 2. Any cognitive disorder, mental disorder or failure to finish the questionnaire and all the examinations 3. Combined glaucoma, age-related macular degeneration, glaucoma, vitreous macular disease (vitreous haemorrhage, retinal detachment), amblyopia and other eye diseases 4. A history of intraocular surgery, such as retinal laser, intraocular anti-VEGF injection, glaucoma surgery, cataract surgery, laser myopia surgery and vitreoretinal surgery history 5. A failure of mydriasis due to corneal ulcer, severe refractive media turbidity or shallow anterior chamber and angle closure glaucoma

Design outcomes

Primary

MeasureTime frame
Prevalence, incidence and progression rates of DR, measured using grading of OCT results annually for 5 years

Secondary

MeasureTime frame
There are no secondary outcome measures

Countries

China

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026