Trial of local anaesthetic nerve blocks for hip fracture pain relief in prehospital care, compared to usual care (morphine), given by paramedics

Randomised trial of clinical and cost effectiveness of Administration of Prehospital fascia Iliaca compartment block for emergency hip fracture care Delivery (RAPID2)

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN15831813

Enrollment

1404

Registered

2021-09-22

Start date

2021-10-01

Completion date

Unknown

Last updated

2026-08-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain relief of patients with hip fracture in prehospital care Musculoskeletal Diseases

Interventions

Usual care Currently, when a patient who has called 999 is attended by a paramedic for a suspected hip fracture, the paramedic clinically assesses the patient, takes their history, examines them and

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Adult patients attended by a participating study paramedic following a 999 call who are: 1. Assessed as having an isolated hip fracture – hip fracture assessment checklists will be provided to aid recognition 2. Conscious (Glasgow Coma Scale Score of =13) 3. Haemodynamically stable 4. To be conveyed to a participating receiving hospital

Exclusion criteria

Exclusion criteria: 1. Taking anticoagulants 2. Have a hip prosthesis on the affected side 3. Refuse analgesia 4. Are thought to be having a stroke 5. Are combative 6. Are attended by a paramedic working alone

Design outcomes

Primary

Measure	Time frame
Pain measured using an eleven point numeric rating scale (0-10) pre-randomisation and on arrival at the emergency department	—

Secondary

Measure	Time frame
1. Routine data taken from patient records: 1.1. Ambulance service job cycle time (from 999 call to ‘ambulance free’) 1.2. Analgesia and anti-emetics administered prehospitally, including morphine and ‘rescue morphine’ 1.3. Length of stay in hospital, ITU and residential rehabilitation care following injury 1.4. Subsequent ED attendances and emergency admissions 1.5. Mortality 1.6. Diagnosis (for patients who did not have a hip fracture) 1.7. Where patient was admitted from and discharged to 2. Patient-reported outcomes: 2.1. Satisfaction with care (Quality of Care Monitor at one month) 2.2. Health related quality of life (HRQoL) (EQ-5D-5L at one and four months) 2.3. Mobility (Rivermead Mobility Index at one and four months. One question will be removed to enable to patient to complete the questionnaire by themselves) 3. Costs to the NHS: This includes all the costs (excluding research costs) sustained to deliver the intervention. A purposely designed data collection questionnaire tested in the feasibility study will be sent to each recruiting site at the end of the study	—

Measure

Time frame

1. Routine data taken from patient records: 1.1. Ambulance service job cycle time (from 999 call to ‘ambulance free’) 1.2. Analgesia and anti-emetics administered prehospitally, including morphine and ‘rescue morphine’ 1.3. Length of stay in hospital, ITU and residential rehabilitation care following injury 1.4. Subsequent ED attendances and emergency admissions 1.5. Mortality 1.6. Diagnosis (for patients who did not have a hip fracture) 1.7. Where patient was admitted from and discharged to 2. Patient-reported outcomes: 2.1. Satisfaction with care (Quality of Care Monitor at one month) 2.2. Health related quality of life (HRQoL) (EQ-5D-5L at one and four months) 2.3. Mobility (Rivermead Mobility Index at one and four months. One question will be removed to enable to patient to complete the questionnaire by themselves) 3. Costs to the NHS: This includes all the costs (excluding research costs) sustained to deliver the intervention. A purposely designed data collection questionnaire tested in the feasibility study will be sent to each recruiting site at the end of the study

—

Countries

England, United Kingdom, Wales

Contacts

Public ContactMark Kingston

m.r.kingston@swansea.ac.uk+44 (0)1792 606844

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Aug 25, 2026