Vestibular threshold degregation Ear, Nose and Throat
Conditions
Interventions
We will compare individual pre- and post-training performance, as well as group pre- and post-training performance. There will be 3 groups: vestibular stimulation training, Tai Chi training, and no tr
Sponsors
University of Bern
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Healthy participants from the age of 65 with no neurological diagnosis or physical disabilities within the Bern region will be recruited for this study.
Exclusion criteria
Exclusion criteria: 1. Neurologic signs indicative of vertigo due to a central lesion 2. Patients with additional severe cardio-vascular, metabolic, neurological, or degenerative diseases 3. Ear/Vestibular diseases or disorders 4. Intake of neuroleptics or other medication with potential effects on cognition or cause nausea 5. Pregnancy 6. Persons with a pacemaker or other metal in the body which could interfere with the scanner. 7. Implantable Cardioverter Defibrillator 8. Hearing loss 9. Cochlea implant 10. Epilepsy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. For the vestibular perceptual threshold (VPT) we measure whether the participants can feel in which direction they have been moved (threshold) to either the left or right using a motion device on day 1 (baseline), day 10 (post training), day 40 (follow-up 1), and day 90 (follow-up 2). 2. For the VestEPs we measure the ERP amplitudes (P1, N1. P2) on day 1 (baseline), day 10 (post training), day 40 (follow-up 1), and day 90 (follow-up 2). 3. With the rs-fMRI we measure Connectivity within the cortical vestibular network (OP2, Csv), Connectivity between the vestibular (OP2) and motor system (M1), and cortical thickness on day 1 (baseline), day 10 (post training), day 40 (follow-up 1), and day 90 (follow-up 2). 4. For gait and posture, we measure the acceleration signals on day 1 (baseline), day 10 (post training), day 40 (follow-up 1), and day 90 (follow-up 2). | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. For the VPT we measure the response times on day 1 (baseline), day 10 (post training), day 40 (follow-up 1), and day 90 (follow-up 2). 2. For the VestEPs we measure the latencies of the ERP amplitudes, time-frequency decomposition analysis of the ERPs, source localization of the ERPs, and a dynamic causal model (DCM) describing the within network alterations over time on day 1 (baseline), day 10 (post training), day 40 (follow-up 1), and day 90 (follow-up 2). 3. For the rs-fMIR we measure volumetric changes on day 1 (baseline), day 10 (post training), day 40 (follow-up 1), and day 90 (follow-up 2). 4. For gait we measure walking duration for the predefined distance on day 1 (baseline), day 10 (post training), day 40 (follow-up 1), and day 90 (follow-up 2). 5. For posture we measure on the stair-condition if participants make use of the hand grip on day 1 (baseline), day 10 (post training), day 40 (follow-up 1), and day 90 (follow-up 2). | — |
Countries
Switzerland
Contacts
Public ContactMatthias Ertl
Outcome results
None listed