Influence of amino acids on muscle preservation and functional improvements in obese, elderly adults

Once/day provision of essential amino acid enriched meal replacement improves body composition and physical function in obese elderly: a randomized controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN15814848

Enrollment

Registered

2021-02-12

Start date

2017-09-07

Completion date

Unknown

Last updated

2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Body composition, skeletal muscle, intrahepatic lipid and physical function in obese elderly individuals Nutritional, Metabolic, Endocrine

Interventions

A computerized random number generator is used for group assignment. An individual not affiliated with this study or the academic program is responsible for blinding of the meal replacements. Individu

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Individuals from all racial, ethnic and/or cultural backgrounds 2. Between the ages of 60-85 years old 3. Body mass index of 26-40 kg/m²

Exclusion criteria

Exclusion criteria: 1. Individuals with a pacemaker or other implanted metal device or object 2. Previously diagnosed with insulin-dependent diabetes, active cancer or malignancy, or a chronic inflammatory condition 3. Individuals taking medications, supplements or corticosteroids that might influence metabolism or corticosteroids 4. Any individual with a disease or condition that places them at risk or harm to themselves or others

Design outcomes

Primary

Measure	Time frame
Measured during pre-supplementation and post-supplementation visits 4 weeks apart: 1. Body weight and height measured using an electronic scale/stadiometer (Health-O-Meter, St. McCook, IL, USA) 2. Body composition measured using a dual-energy x-ray absorptiometry scanner (General Electric Lunar iDXA, Madison, WI) 3. Thigh skeletal muscle cross-sectional area and intrahepatic lipid measured using a molecular resonance imaging/spectroscopy (Toshiba Excelart/Vantage 1.5 T MRI/MRS imaging system, Canon, Otawara, Tochigi, Japan), muscle cross-sectional area further quantified using Osirix (Geneva, Switzerland) 4. Physical function parameters including measurements of grip strength, floor transfer time and walking distance/speed	—

Measure

Time frame

Measured during pre-supplementation and post-supplementation visits 4 weeks apart: 1. Body weight and height measured using an electronic scale/stadiometer (Health-O-Meter, St. McCook, IL, USA) 2. Body composition measured using a dual-energy x-ray absorptiometry scanner (General Electric Lunar iDXA, Madison, WI) 3. Thigh skeletal muscle cross-sectional area and intrahepatic lipid measured using a molecular resonance imaging/spectroscopy (Toshiba Excelart/Vantage 1.5 T MRI/MRS imaging system, Canon, Otawara, Tochigi, Japan), muscle cross-sectional area further quantified using Osirix (Geneva, Switzerland) 4. Physical function parameters including measurements of grip strength, floor transfer time and walking distance/speed

—

Secondary

Measure	Time frame
Measured during pre-supplementation and post-supplementation visits 4 weeks apart: 1. Blood samples collected and analyzed for metabolic, lipid and hepatic blood panels by LabCorp (1626 30th Avenue, Fairbanks, AK) 2. Bone mineral density measured using a dual-energy x-ray absorptiometry scanner (General Electric Lunar iDXA, Madison, WI)	—

Countries

United States of America

Contacts

Public ContactRobert Coker

rcoker@alaska.edu+1 (0)907 474 6701

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 14, 2026