Signs and Symptoms: Sepsis Signs and Symptoms Sepsis
Conditions
Interventions
Patients will be recruited from the elective colorectal admissions at Scarborough Hospital and will be randomised by a series of sealed envelopes into one of the four groups when they are seen in the
Sponsors
Record Provided by the NHSTCT Register - 2005 Update - Department of Health (UK)
Eligibility
Inclusion criteria
Inclusion criteria: Using bacterial translocation as the primary end point for sample size calculation, if the sample size in each of the 4 groups is 20, alpha=0.05 (2-tailed) a chi-square test will have 80% power to detect a difference in proportions.
Exclusion criteria
Exclusion criteria: Failure to obtain informed consent, patients with co-existing infections, patients on antibiotics in the previous 2 weeks before recruitment and patients with severe hepatic or renal failure.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gut microflora: 1. Nasogastric aspirate 2. Fecal samples. Gut barrier function: 1. Bacterial Translocation 2. Intestinal Permeability. Inflammatory response: 1. C reactive protein (CRP) 2. Interleukin-6 (IL-6) 3. AntiEndotoxin core antibody (IgM Endo CAB). Septic morbidity: 1. Wound infection 2. Intra-abdominal abscess 3. Chest Infection 4. UTI. | — |
Secondary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Countries
United Kingdom
Outcome results
None listed