Asthma-like symptoms Respiratory Asthma
Conditions
Interventions
16 Child Health Centres in Rotterdam are participating. These Child Health Centres were first stratified for the socioeconomic status of their neighbourhood and then randomised into 8 intervention Chi
just routine procedure will be enhanced.
The early detection questionnaire contains 4 questions, based on selected and adapted questions from the International Studies of Asthma and Allergies in Chil
Sponsors
The Netherlands Organisation for Health Research and Development (ZonMw) (Netherlands)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The Generation R cohort includes 9778 mothers and their children. Of the 9778 women who enrolled in pregnancy, 7893 children participated in the post-natal cohort. The study population of this trial consists of all 7893 children who will be invited for a preventive health check by the 16 participating Child Health Centres in Rotterdam at age 14, 24, 36 and 45 months.
Exclusion criteria
Exclusion criteria: Children not participating the Generation R study who visit the 16 participating Child Health Centres in Rotterdam.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Frequency of asthma-like symptoms-questionnaire (last 4 weeks/12 months): International study of asthma and allergies in childhood/prevention and incidence of asthma and mite allergy (ISAAC/PIAMA) (wheezing, snoring breath, shortness of breath or dyspnoea) 2. Generic health-related quality of life of the child (last 4 weeks): Health Utilities Index 2/3; Child Health Questionnaire-Infant/Toddler Follow-up: 1. Multi-RAST/Phadiatop-test (blood samples by Generation R): as indicator of allergic sensitisation 2. Micro-Rint: lung function 3. Exhaled nitric oxide (NO): asthmatic airway inflammation Timepoints of measurement: Age 14 months: preventive health check (June 2003 - June 2007) Age 24 months: preventive health check (June 2004 - June 2008) Age 36 months: preventive health check (June 2005 - June 2009) Age 45 months: preventive health check (June 2006 - June 2010) Age 5 years: follow-up measurements (November 2008 - November 2012) In the future, within Generation R, outcomes at older ages, even into adulthood, may be measured. | — |
Secondary
| Measure | Time frame |
|---|---|
| Doctor diagnosed asthma - (question to parent(s): has a doctor ever diagnosed asthma in your child?) Data on covariates will be gathered via procedures within the Generation R study from pharmacists, general practitioners, hospitals and questionnaires from parents, given informed consent. | — |
Countries
Netherlands
Outcome results
None listed