Renal cancer Cancer Renal cancer
Conditions
Interventions
Dual source computed tomography including dual-energy CT (DECT) and perfusion-CT (CTp) quantification of vascularisation pre- and day 1 post-ablation improves the assessment of residual disease versus
Sponsors
Guy's and St Thomas' and King's College London
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients with T1 renal tumours referred for ablation
Exclusion criteria
Exclusion criteria: 1. Standard contraindications for contrast-enhanced CT including poor renal function (as per hospital protocol) 2. Previous contrast agent allergy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Sensitivity and specificity for residual and recurrent disease measured by i) morphological CT; ii) DECT iodine distribution; iii) CTp BF, BV and PS at baseline, 3-months, 9-months 2. Quantitative cut-offs that maximise sensitivity for residual and recurrent disease | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Correlations between DECT and CTp parameters 2. Reproducibility of DECT and CTp parameters 3. Differences CTp measurements between d1 and d14 | — |
Countries
England, United Kingdom
Contacts
Public ContactAdedayo Oke
Outcome results
None listed