Prevention of pre-diabetes in overweight and obese adults Nutritional, Metabolic, Endocrine
Conditions
Interventions
The randomization sequence was generated with an online statistical package (https://www.randomization.com). Participants were blinded to the order of the conditions until the commencement of each con
Sponsors
Zhejiang University
Eligibility
Sex/Gender
Male
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: 1. Healthy Chinese men aged 18-35 years old 2. Overweight or obese (BMI =24 kg/m2) 3. Sedentary (self-reported sitting time >6 h per day for last 2 months), physically inactive (not meeting the physical activity guideline of =150 min per week of moderate-intensity or =75 min per week of vigorous-intensity exercise for last 2 months) 4. Free of diabetes and cardiovascular diseases (fasting glucose =6.1 mmol/l) and nonsmoker
Exclusion criteria
Exclusion criteria: 1. Self-reported chronic, long-term musculoskeletal disease 2. Cardiovascular or metabolic disease requiring medication known to affect metabolism 3. Change of body weight >2 kg in the past 2 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postprandial glucose measured using a continuous glucose monitor (CGM) throughout the 8.5-h intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Muscle activity measured using textile EMG shorts throughout the 8.5-h intervention 2. Heart rate measured using a heart rate belt throughout the 8.5-h intervention 3. Physical activity measured using accelerometry 2 days before each condition 4. Food intake measured using self-reported dialogue 2 days before each condition 5. Blood pressure measured using an electronic blood pressure monitor every 45 minutes during the measurement (beginning, 1:00, 1:45, 2:30, 3:15, 4:00, 4:45, 5:30, 6:15, 7:00, 7:45, and 8:30 of the experiment time) 6. Perceived feelings, including shoulder, upper limbs, waist, hip, and lower limbs discomfort, fatigue, and working efficiency, measured using a visual analogue scale every 45 minutes during the measurement (beginning, 1:00, 1:45, 2:30, 3:15, 4:00, 4:45, 5:30, 6:15, 7:00, 7:45, and 8:30 of the experiment time) 7. Energy expenditure of daily physical activity tasks, including supine, sitting, standing, walking, running, and squatting, measured using K5 indirect calorimetry 1 week before the intervention 8. Body composition, including body mass, fat mass, muscle mass, and liver fat index, measured using a bioelectrical impedance device 1 week before the intervention 9. Leg swelling measured using a self-made water tank (water displacement method) before and after each condition | — |
Countries
China
Outcome results
None listed