Comparison between the effects of a 12-hour light-dark cycle and continuous 24-hour hospital lighting in preterm infants under 36 weeks of gestation

Effects of a 12-hour light-dark cycle compared to continuous 24-hour lighting on clinical outcomes and length of hospital stay in preterm infants under 36 weeks of gestation in the Neonatal Intensive Care Unit of the Hospital General Regional 72, Instituto Mexicano del Seguro Social

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN15688312

Enrollment

Registered

2026-07-30

Start date

2026-07-23

Completion date

Unknown

Last updated

2026-08-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Circadian rhythm disruption in preterm infants in the NICU Neonatal Diseases

Interventions

A controlled clinical trial was conducted in the Neonatal Intensive Care Unit (NICU) of Hospital General Regional 72 of the Instituto Mexicano del Seguro Social (IMSS), located in Tlalnepantla, State

Eligibility

Sex/Gender

All

Age

26 Weeks to 36 Weeks

Inclusion criteria

Inclusion criteria: 1. Preterm infants between 26 and 36 weeks of gestational age 2. Patients admitted to the Neonatal Intensive Care Unit (NICU) of the Hospital General Regional 72,Instituto Mexicano del Seguro Social (IMSS) 3. Informed consent signed by parents or legal guardians

Exclusion criteria

Exclusion criteria: 1. Lethal congenital malformations 2. Trisomies 3. Structural defects or malformations

Design outcomes

Primary

Measure	Time frame
Length of hospital stay measured using days at between baseline/initial time point: second day of life/admission to the Neonatal Intensive Care Unit (NICU) and final time point: hospital discharge;Time to iInitiation of enteral feeding measured using days at between baseline/initial time point: second day of life/admission to the Neonatal Intensive Care Unit (NICU) and final time point: hospital discharge;Duration of mechanical ventilation measured using days at between baseline/initial time point: second day of life/admission to the Neonatal Intensive Care Unit (NICU) and final time point: hospital discharge	—

Measure

Time frame

Length of hospital stay measured using days at between baseline/initial time point: second day of life/admission to the Neonatal Intensive Care Unit (NICU) and final time point: hospital discharge;Time to iInitiation of enteral feeding measured using days at between baseline/initial time point: second day of life/admission to the Neonatal Intensive Care Unit (NICU) and final time point: hospital discharge;Duration of mechanical ventilation measured using days at between baseline/initial time point: second day of life/admission to the Neonatal Intensive Care Unit (NICU) and final time point: hospital discharge

—

Secondary

Measure	Time frame
Weight measured using grams (g) at between baseline/initial time point: second day of life/admission to the Neonatal Intensive Care Unit (NICU) and final time point: hospital discharge;Length measured using centimeters (cm) at between baseline/initial time point: second day of life/admission to the Neonatal Intensive Care Unit (NICU) and final time point: hospital discharge;Head circumference measured using centimeters (cm) at between baseline/initial time point: second day of life/admission to the Neonatal Intensive Care Unit (NICU) and final time point: hospital discharge;Time to full enteral feeding measured using days at between baseline/initial time point: second day of life/admission to the Neonatal Intensive Care Unit (NICU) and final time point: hospital discharge;Duration of supplemental oxygen requirement measured using days at between baseline/initial time point: second day of life/admission to the Neonatal Intensive Care Unit (NICU) and final time point: hospital discharge	—

Measure

Time frame

Weight measured using grams (g) at between baseline/initial time point: second day of life/admission to the Neonatal Intensive Care Unit (NICU) and final time point: hospital discharge;Length measured using centimeters (cm) at between baseline/initial time point: second day of life/admission to the Neonatal Intensive Care Unit (NICU) and final time point: hospital discharge;Head circumference measured using centimeters (cm) at between baseline/initial time point: second day of life/admission to the Neonatal Intensive Care Unit (NICU) and final time point: hospital discharge;Time to full enteral feeding measured using days at between baseline/initial time point: second day of life/admission to the Neonatal Intensive Care Unit (NICU) and final time point: hospital discharge;Duration of supplemental oxygen requirement measured using days at between baseline/initial time point: second day of life/admission to the Neonatal Intensive Care Unit (NICU) and final time point: hospital discharge

—

Countries

Mexico

Contacts

Public ContactPaola Gabriela;Emilio Arévalo Morles;Domínguez Garibay

;

parevalom2200@alumno.ipn.mx;edominguezg2200@alumno.ipn.mx+52 55 9111 5904;+52 55 435 92625

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Aug 25, 2026