Panic disorder with agoraphobia Mental and Behavioural Disorders Other anxiety disorders
Conditions
Interventions
Eight sessions of standardised and manualised cognitive behavioural group-therapy for panic disorder and agoraphobia plus three individual exposure therapy sessions employing flooding technique, were
Sponsors
Charité - University Medicine Berlin (Charité - Universitätsmedizin Berlin) (Germany)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Subject familiarised with experimental procedure and had given written informed consent 2. Diagnosis of panic disorder with agoraphobia according to Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM IV), at least "moderately ill" 3. Aged 18 - 75 years, either sex 4. Sufficiently able to communicate with investigator, answer questions and fill in questionnaires 5. Reachability of patient for treatment and follow-up 6. Complience of patient 7. Undisturbed day-night rhythm
Exclusion criteria
Exclusion criteria: 1. Inability to give informed consent 2. Hospitalisation in a mental institution 3. Other psychiatric illnesses like schizophrenia, substance abuse or dementia 4. Acute suicidal tendency 5. Epilepsy or other illness of the central nervous system (CNS) (e.g. brain tumour, encephalitis) 6. Severe internal medical illness, e.g., severe hypertension, severe cardiac insufficiency, condition after acute myocardial infarction, cardiac arrhythmia of severity index IV or V according to Lown grade, severe dysfunction of liver or kidney, diabetes mellitus requiring insulin treatment, disturbances of haematopoiesis 7. Pregnancy or breastfeeding 8. Changes of psychopharmacological treatment within the last 8 weeks or discontinuation of psychopharmacological treatment within less than 2 weeks before beginning of the study 9. Recent interference with diurnal cycle 10. Current psychotherapeutic treatment specific for panic disorder and/or agoraphobia 11. Participation in other study within last month before beginning of the study or during the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Concentrations of cortisol and adrenocorticotropin hormone (ACTH) during exposure training 2. Panic and Agoraphobia Scale after therapy and at follow-up | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Mobility Inventory for Agoraphobia after therapy and at follow-up 2. Beck Depression Inventory after therapy and at follow-up 3. Beck Anxiety Inventory after therapy and at follow-up 4. Hamilton Rating Scale for Depression after therapy and at follow-up 5. Hamilton Rating Scale for Anxiety after therapy and at follow-up 6. Clinical Global Impression after therapy and at follow-up | — |
Countries
Germany
Outcome results
None listed