A new method (nanosurgery and bioengineering treatment) of non-operative treatment of anterior cruciate ligament tears

Nano-surgical and bioengineering treatment of human anterior cruciate ligament tears with ultrasound-guided RP-hCM intake based on clinical, ultrasound, MRI, and nano-scope analyses

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN15642019

Enrollment

Registered

2023-04-12

Start date

2015-01-01

Completion date

Unknown

Last updated

2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-operative treatment of anterior cruciate ligament tears Injury, Occupational Diseases, Poisoning

Interventions

Nanosurgery and bioengineering treatment (NSBT) under ultrasound guidance. Clinical exam-prospective, blind comparison to the gold standard. The study uses a simple randomization model - sequentially

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Positive Lachman and pivot shift test in physical examination 2. ACL tear confirmed in ultrasound and MRI examinations 3. No other coexisting injuries of the knee that would change treatment options to the operative procedure 4. Patient’s signed informed consent to enrol in the trial

Exclusion criteria

Exclusion criteria: 1. Pregnancy 2. No patient signed informed consent to enrol in the trial

Design outcomes

Primary

Measure	Time frame
1. Pain measured using a visual analog scale (VAS) before treatment (1 day before NSBT) and after NSBT at baseline 24, 48 hours and next in 10 - 12 weeks 2. Patients' functional status in daily activities and pain assessed using the following measures before treatment (1 day before NSBT) and at the baseline 24, 48 hours and in 10 - 12 weeks: 2.1. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) 2.2. The Lysholm Knee scoring 3. Clinical knee instability measured using a physical examination and in Lachman test at baseline	—

Measure

Time frame

1. Pain measured using a visual analog scale (VAS) before treatment (1 day before NSBT) and after NSBT at baseline 24, 48 hours and next in 10 - 12 weeks 2. Patients' functional status in daily activities and pain assessed using the following measures before treatment (1 day before NSBT) and at the baseline 24, 48 hours and in 10 - 12 weeks: 2.1. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) 2.2. The Lysholm Knee scoring 3. Clinical knee instability measured using a physical examination and in Lachman test at baseline

—

Countries

Poland

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 5, 2026