Prevention of secondary development of intrauterine adhesions in patients after hysteroscopic treatment of Asherman's syndrome Urological and Genital Diseases
Conditions
Interventions
Patients eligible for the trial will be divided into two groups (group A = study group, group B = control group) with a 1:1 allocation ratio by pulling the letter A or B out of the envelope. Patients
Sponsors
Charles University
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Women aged 18-45 years 2. Seeking pregnancy in the future 3. Confirmed Asherman's syndrome by hysteroscopy 4. Consent to their participation in the trial
Exclusion criteria
Exclusion criteria: 1. Do not wish to participate in the study 2. Women out of the age range from 18 to 45 years 3. Do not meet the diagnostic criteria of Asherman's syndrome 4. Known hypersensitivity to the components of Hyalobarrier gel or 4DryField 5. Inability to perform a sufficient surgical treatment during the initial hysteroscopy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The overall assessment of the uterine cavity during the second-look hysteroscopy (1 month after the primary hysteroscopic adhesiolysis) will be done by three skilled surgeons participating in the trial. The presence and severity of de-novo adhesions will be measured using the American Fertility Society score of intrauterine adhesions at that point. | — |
Secondary
| Measure | Time frame |
|---|---|
| Reproductive outcomes of all study patients will be recorded (annual check-ups) and evaluated for 2-5 years. The following reproductive parameters will be observed: pregnancy rate, abortion rate, live-birth rate, pregnancy complication rate), time to conception, mode of conception. | — |
Countries
Czech Republic
Contacts
Public ContactZdenka Lisa
Outcome results
None listed