Investigation of glucose and insulin levels, using oral glucose tolerance testing, in response to active compounds derived from protein

A randomized, controlled, crossover design study to investigate postprandial glucose levels of participants in response to proteins, using an oral glucose tolerance test (OGTT)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN15620029

Enrollment

Registered

2021-03-31

Start date

2017-10-01

Completion date

Unknown

Last updated

2021-04-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postprandially stimulated insulin secretion and blood glucose control Nutritional, Metabolic, Endocrine

Interventions

An Oral Glucose Tolerence Test (OGTT) accompanied by a protein drink. Drink 1 – 75 g glucose in 200 ml water + 15 g Intact Whey protein in 100 ml water Drink 2 – 75 g g

a total of 180 ml of blood. A bed will be provided to rest on. A desk will also be available if volunteers wish to read, study or use a laptop. There will be wireless internet available and if partici

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged >18 and 18.5 and < 30 kg/m² 3. Generally healthy free living in the community 4. Males and females

Exclusion criteria

Exclusion criteria: 1. Aged below 18 years and above 45 years 2. BMI > 30 kg/m², <18.5kg/m² 3. Diagnosis chronic or infectious disease 4. Taking of any medication (exception OCP) 5. Pregnancy or breastfeeding 6. Have an allergy or intolerance to dairy or rice products

Design outcomes

Primary

Measure	Time frame
Blood glucose levels measured using venous blood samples taken at baseline, then 15, 30, 60, 90- and 120-min post intervention	—

Secondary

Measure	Time frame
1. Plasma insulin response measured using venous blood samples taken at baseline, then 15, 30, 60, 90- and 120-min post intervention 2. Amino-acid, fatty acid or TCA cycle intermediate metabolism measured using venous blood samples taken at baseline, then 15, 30, 60, 90- and 120-min post intervention 3. C-peptide production measured using venous blood samples taken at baseline, then 15, 30, 60, 90- and 120-min post intervention	—

Measure

Time frame

1. Plasma insulin response measured using venous blood samples taken at baseline, then 15, 30, 60, 90- and 120-min post intervention 2. Amino-acid, fatty acid or TCA cycle intermediate metabolism measured using venous blood samples taken at baseline, then 15, 30, 60, 90- and 120-min post intervention 3. C-peptide production measured using venous blood samples taken at baseline, then 15, 30, 60, 90- and 120-min post intervention

—

Countries

Ireland

Contacts

Public ContactClaire Erraught

claire.erraught@ucdconnect.ie+353 (0)868618967

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026