COVID-19 (SARS-CoV-2 infection) Infections and Infestations
Conditions
Interventions
Patients who have had a test for COVID-19 will be invited to take part in the study. During their clinical research visit, a medical history will be taken, a physical examination performed and blood t
Sponsors
Imperial College London
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients aged =18 years with a clinical suspicion of COVID-19 infection will be invited to take part in the study. Those with a diagnosis of COVID-19, either on the basis of a positive result from real-time RT-PCR testing of a nasopharyngeal swab, or based on diagnostic clinical and radiological findings will be included in the COVID-19 group.
Exclusion criteria
Exclusion criteria: 1. History of any medical, psychological or other condition, or use of any medications, including over-the-counter products, which, in the opinion of the investigators, would either interfere with the study or potentially cause harm to the participant. 2. History of blood donation within the past 3 months, or the intention to do so within 3 months of completing the study 3. Being pregnant or breastfeeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The proportion of patients with confirmed COVID-19 who show evidence of adrenal insufficiency on a short Synacthen test =3 months following their presentation with suspected COVID-19 | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome measures will include the following: 1. Proportion of patients previously diagnosed with COVID-19 with evidence of adrenal insufficiency on their first short Synacthen test who show adrenal recovery at subsequent visits at months 3, 6 and 9 months after initial study visit, whereby the first study visit takes place at least 3 months after initial presentation 2. Proportion of patients previously diagnosed with COVID-19 with evidence of other hormone disturbances (including thyroid and reproductive hormones) measured using serum thyroid function tests and serum reproductive hormone tests (LH, FSH, testosterone and oestradiol) at least 3 months after initial presentation | — |
Countries
England, United Kingdom
Contacts
Public ContactSophie Clarke
Outcome results
None listed