The effect of two different fats (medium chain triglycerides and long chain triglycerides) combined with exercise on energy balance

The effect of triglyceride chain length combined with exercise on appetite, satiety and energy balance

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN15611082

Enrollment

Registered

2017-04-19

Start date

2016-09-01

Completion date

Unknown

Last updated

2020-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Energy balance Nutritional, Metabolic, Endocrine

Interventions

Following provision of informed consent and study screening, which includes a VO2max test, eligible participants are given weighing scales and a standardisation booklet in order to fulfil standardisat

or rest for two hours, cycle for an hour at 65% VO2max and then rest for the remaining hour (exercise trials) until an ad libitum lunch is served. Gastric emptying breath tests are taken every 15 minu

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: 1. Aged 18-65 2. Male 3. BMI of 18.5-29.9 kg/m2

Exclusion criteria

Exclusion criteria: 1. Allergic/intolerant to any of the foods provided in the study 2. Taking medication which could affect appetite 3. Smokers 4. A ‘restrained eater’, as defined by the TFEQ and DEBQ 5. Not weight stable (losing/gaining 3kg in the last 3 months) 6. Currently dieting to lose weight

Design outcomes

Primary

Measure	Time frame
1. Energy intake, assessed by the ad libitum buffet lunch that participants consume at the end of trials in the lab at 255–285 mins 2. Subjective sensations of appetite (hunger, fullness, desire to eat, prospective food consumption and nausea), measured using Visual Analogue Scales at 0 mins, 10 mins, 30 mins, 60 mins, 90 mins, 120 mins, 180 mins, 210 mins, 240 mins and 285 mins 3. Energy balance, measured using the CPX Ultima and combined with energy intake data, at -30 mins – 0 mins, 30 mins – 45 mins, 60 mins – 75 mins, 90 mins – 105 mins, 120 mins – 180 mins, 210 mins – 225 mins, 240 mins – 255 mins	—

Measure

Time frame

1. Energy intake, assessed by the ad libitum buffet lunch that participants consume at the end of trials in the lab at 255–285 mins 2. Subjective sensations of appetite (hunger, fullness, desire to eat, prospective food consumption and nausea), measured using Visual Analogue Scales at 0 mins, 10 mins, 30 mins, 60 mins, 90 mins, 120 mins, 180 mins, 210 mins, 240 mins and 285 mins 3. Energy balance, measured using the CPX Ultima and combined with energy intake data, at -30 mins – 0 mins, 30 mins – 45 mins, 60 mins – 75 mins, 90 mins – 105 mins, 120 mins – 180 mins, 210 mins – 225 mins, 240 mins – 255 mins

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Secondary

Measure	Time frame
1. 24 hour energy intake, measured using recorded diet diaries completed after the morning in the lab 2. Gastrointestinal distress (to identify any adverse effects associated with the lipids), measured using a GI Distress questionnaire on the morning following the lab visit 3. Gastric emptying, measured through the 13C octanoic acid breath test at 0 min, 15 min, 30 min, 45 min, 60 min, 75 min, 90 min, 105 min, 120 min, 135 min, 150 min, 165 min, 180 min, 195 min, 210 min, 225 min, 240 min, 285 min 4. Hedonic properties of the lipid (to outline palatability issues with the breakfasts which may confound the results), assessed by Quantitative Descriptive Analysis at 10 min	—

Measure

Time frame

1. 24 hour energy intake, measured using recorded diet diaries completed after the morning in the lab 2. Gastrointestinal distress (to identify any adverse effects associated with the lipids), measured using a GI Distress questionnaire on the morning following the lab visit 3. Gastric emptying, measured through the 13C octanoic acid breath test at 0 min, 15 min, 30 min, 45 min, 60 min, 75 min, 90 min, 105 min, 120 min, 135 min, 150 min, 165 min, 180 min, 195 min, 210 min, 225 min, 240 min, 285 min 4. Hedonic properties of the lipid (to outline palatability issues with the breakfasts which may confound the results), assessed by Quantitative Descriptive Analysis at 10 min

—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026