How do dental injections make your lower teeth go numb?

A double-blind cross-over trial with healthy adult volunteers comparing molar buccal infiltrations to canine buccal infiltrations for anaesthesia of mandibular teeth

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN15594715

Enrollment

Registered

2012-04-11

Start date

2012-02-06

Completion date

Unknown

Last updated

2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental local anaesthesia Oral Health

Interventions

1.8ml 4% articaine hydrochloride with 1:100000 adrenaline injected in the mucobuccal fold opposite either the lower 1st molar, 2nd molar or canine tooth. Placebo is needle penetration only.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Volunteers that are aged 18-30 years, with vital molar, first and second premolar, canine and incisor teeth that are not restored.

Exclusion criteria

Exclusion criteria: 1. Volunteers that are under 18 or over 30 years of age 2. Those unable to give consent 3. Those with self reported bleeding disorders, orofacial anaesthesia or paraesthesia, allergies to local anaesthetic drugs, preganancy at time of study or with teeth that respond negatively to baseline pulp testing or key test teeth missing

Design outcomes

Primary

Measure	Time frame
Response to electronic pulp testing indicating pulpal anaesthesia	—

Secondary

Measure	Time frame
Injection discomfort using a Visual Analogue Scale	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026