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Can repeated blood tests for heparin-binding protein concentration predict who will die from sepsis?

Predicting 90-day survival in septic ICU patients: a post-hoc study of longitudinal heparin-binding protein measures from the FINNAKI cohort

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ISRCTN
Registry ID
ISRCTN15560762
Enrollment
652
Registered
2020-12-03
Start date
2011-09-01
Completion date
Unknown
Last updated
2021-05-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis and septic shock Infections and Infestations Sepsis, unspecified

Interventions

The researchers will analyze HBP concentration on repeated plasma samples collected from patients in the FINNAKI study at 0, 12, 24, 36, 48, 72 and 120 hours from intensive care unit admission using

Sponsors

Lund University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Patients included in the FINNAKi study, i.e. all emergency intensive care unit admissions aged >18 years and all elective patients aged >18 years with an intensive care unit stay longer than 24 h 2. Who had severe sepsis or septic shock diagnosed on the day of intensive care unit admission 3. Who had at least one plasma sample available from the first five days of ICU stay

Exclusion criteria

Exclusion criteria: Exclusion criteria for the FINNAKI study: 1. End-stage renal disease requiring maintenance dialysis 2. Organ donors 3. Received intermediate care 4. Received renal replacement therapy (RRT) while enrolled in the study during a previous ICU admission 5. Transferred from another ICU where the data collection for the study was fulfilled 6. Not permanently living in Finland or unable to give consent due to insufficient language skills

Design outcomes

Primary

MeasureTime frame
Number of days alive within 90 days from intensive care unit admission measured using patient records

Secondary

MeasureTime frame
There are no secondary outcome measures

Countries

Finland

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026