Hypertension, treated but uncontrolled Circulatory System Hypertension secondary to other renal disorders
Conditions
Interventions
1. RTGT: The antihypertensive drugs were chosen based on the renin test guided therapeutic (RTGT) algorithm.
2. Senior General Cardiologists? Care (SGCC): The antihypertensive drugs were chosen based
Sponsors
Second Hospital of Hebei Medical University (China)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Established hypertensive patients 2. 18 years or older 3. Male or female of any race or ethnicity 4. Have never had anti-hypertensive medication 5. Have had anti-hypertensive medication but not for at least two weeks
Exclusion criteria
Exclusion criteria: 1. Any comorbidities requiring the medications that interferes with blood pressure (BP) levels (e.g. non-steroidal anti-inflammatory drugs with the exception of aspirin) 2. Any contraindications to any types of antihypertensive drug applied in this study (e.g. asthma) 3. Any situations leading to poor adherence to the study protocol (e.g. mental illness or instability in BP levels e.g. cardiovascular neurosis) 4. Home BP 135/85 mmHg 5. History of white-coat hypertension 6. Serum creatinine >2.5 mg/dl
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differences in change in BPs between RTGT and SGCC groups with the three hypertension subtypes, respectively, and between the three hypertension subtypes within RTGT group. | — |
Secondary
| Measure | Time frame |
|---|---|
| Differences in change in the antihypertensive drug number between RTGT and SGCC groups with the three hypertension subtypes, respectively, and between the three hypertension subtypes within RTGT group. | — |
Countries
China
Outcome results
None listed