The role of ozone on gingival tissue healing after gingivectomy

Evaluation of the efficacy of ozone in healing of inflammatory gingival enlargements after resection by traditional method or by diode laser

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN15523491

Enrollment

Registered

2024-09-05

Start date

2022-07-14

Completion date

Unknown

Last updated

2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inflammatory gingival overgrowth Oral Health

Interventions

The study aims to compare the surgical method and the laser method of gingivectomy and to compare applying ozone after gingivectomy or not applying it in both treatment groups. The patients are rando

Wavelength: 980 nm

Continuous mode CW. The laser cutting session takes approximately 20 minutes, the ozone application takes nearly 15 minutes (no gingival dressing is applied) and the whole working time is approximate

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Grade II-III inflammatory gingival hyperplasia that has not been improved after 15 days of professional and individual periodontal care 2. Pseudo-gingival pockets with a depth of 2 mm and above 3. Patient aged between 18-50 years old 4. Healthy patients without systemic diseases

Exclusion criteria

Exclusion criteria: 1. Pregnant women or those using oral contraceptives 2. Breastfeeding women 3. Smokers 4. Patients treated with nonsteroidal anti-inflammatory drugs and analgesics for 1 month 5. Patients prohibited from undergoing surgery or anesthesia, or patients that have uncontrolled systemic diseases 6. Bad restorations or prosthodontics in the gingival area 7. Localized gingival hyperplasia 8. Patients with drug or hormonal hyperplasia

Design outcomes

Primary

Measure	Time frame
Gingival tissue enlargement measured using Gingival Overgrowth (GO), which has three degrees (0, 1, 2, 3), at baseline and after 15 days (immediately before gingival resection), 1 month and 3 months after resection	—

Secondary

Measure	Time frame
1. Periodontal probing depth (PPD), defined as the distance from the free gingival margin to the bottom of the periodontal pocket. Measured using a periodontal probe (Williams) at baseline and after 15 days (immediately before gingival resection), 1 month and 3 months after resection. 2. Level of gingival inflammation is measured using the Gingival Index (GI) at baseline and after 15 days (immediately before gingival resection), 1 week, 2 weeks, 1 month and 3 months after resection. 3. Pain is measured using a visual analogue scale (VAS) on day 1, day 3, 1 week and 2 weeks after resection 4. Level of healing is measured using the Healing Index (HI), which has five degrees (1, 2, 3, 4, 5) at 1 week, 2 weeks and 1 month after resection	—

Measure

Time frame

1. Periodontal probing depth (PPD), defined as the distance from the free gingival margin to the bottom of the periodontal pocket. Measured using a periodontal probe (Williams) at baseline and after 15 days (immediately before gingival resection), 1 month and 3 months after resection. 2. Level of gingival inflammation is measured using the Gingival Index (GI) at baseline and after 15 days (immediately before gingival resection), 1 week, 2 weeks, 1 month and 3 months after resection. 3. Pain is measured using a visual analogue scale (VAS) on day 1, day 3, 1 week and 2 weeks after resection 4. Level of healing is measured using the Healing Index (HI), which has five degrees (1, 2, 3, 4, 5) at 1 week, 2 weeks and 1 month after resection

—

Countries

Syria

Contacts

Public ContactDana Hussen

dana.hussen@damascusuniversity.edu.sy+963 (0)992185672

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026