Specialty: Reproductive health and childbirth, Primary sub-specialty: Reproductive and Sexual Medicine
Conditions
Interventions
Participants will be randomised in the ratio 1:1 to receive either Eggcell or standard treatment using permuted random blocks of variable length. Randomisation will be stratified by site. An individua
Sponsors
Newcastle upon Tyne Hospitals NHS Foundation Trust
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Women having routine IVF treatment can be considered who have grown =10 and =20 follicles of size >/= 16mm in diameter as seen on the scan prior to hCG injection. 2. Provision of informed consent 3. Aged 23-39 (inclusive)
Exclusion criteria
Exclusion criteria: 1. Women who have grown less than 10 or more than 20 follicles of size 16mm in diameter 2. Unable to give informed consent 3. Insufficient English to allow completion of informed consent and study questionnaire 4. Women with a previous poor recovery rate (<50%) 5. Previous participation in this study 6. Women who have indicated that they do not wish to be involved in research
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Egg recovery rate per patient defined as the number of eggs recovered divided by the number of follicles aspirated is assessed on the egg collection day. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Fertilisation rate defined as the total number of fertilised eggs with 2PN seen on day 1divided by the total number of MII eggs retrieved on the egg collection day (day 1) 2. The number of TOP grade embryos on days 3 (cleavage stage) and 5 (blastocyst). Embryo development will be graded according to the United Kingdom National External Quality Assessment Service (UK NEQAS) grading system - Embryo Morphology Scheme . 3. Early treatment outcome defined as the presence of an intrauterine sac containing at least one foetal pulse per egg collection on day 14/+21 days 4. Implantation rate defined as the total number of foetal pulsations divided by the total number of embryos transferred on day 14/+21 days 5. Live birth rate defined as the total number of babies born divided by the total number of egg collections at 9 months/+3 months 6. Delivery rate per embryo defined as the total number live birth events divided by the total number of embryos transferred at 9 months/+3 months 7. Clinician’s experience of each procedure recorded using a questionnaire designed for the purpose of this study on the egg collection day 8. Embryologist’s experience of each procedure recorded using a questionnaire designed for the purpose of this study on the egg collection day | — |
Countries
England, United Kingdom
Contacts
Public ContactKaren;Chrissie Nicholson;Butcher
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Outcome results
None listed