Atrial fibrillation post cardiac surgery Circulatory System Atrial fibrillation post cardiac surgery
Conditions
Interventions
Patients are randomized at least 12 to 24 hours prior to surgery to receive colchicine or no colchicine in an open label format. Randomization was performed by the principal investigator using an onl
Sponsors
Jordan Collaborative Cardiology Group
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: All adult patients undergoing elective cardiac surgery and cared for by participating cardiologists.
Exclusion criteria
Exclusion criteria: 1. Patients with a documented history of AF or supraventricular arrhythmia or, with absence of sinus rhythm on hospital admission 2. Known severe liver disease or current transaminases >1.5 times the upper normal limit 3. Current serum creatinine >2.5 mg/dl 4. Known myopathy or elevated baseline preoperative creatine kinase 5. Known blood dyscrasias 6. Significant gastrointestinal disease 7. Pregnant and lactating women 8. Known hypersensitivity to colchicine 9. Current treatment with colchicine for any indications 10. Emergency surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Rate of AF is measured through continuous ECG monitoring until the time of discharge. Episodes of AF lasting for 5 minutes or more are continued significant and are recorded. 2. Occurrence of side effects is determined through daily patient examinations and patient interviews until the time of discharge | — |
Countries
Jordan
Contacts
Public ContactRamzi Tabbalat
Outcome results
None listed