Does propofol prevent morphine-induced nausea, vomiting and itching in women who have had a Caesarean section?

A sub-hypnotic dose of propofol as antiemetic prophylaxis attenuates intrathecal morphine-induced postoperative nausea and vomiting, and pruritus in cesarean section

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN15475205

Enrollment

400

Registered

2019-04-03

Start date

2016-05-26

Completion date

Unknown

Last updated

2019-10-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Morphine-induced postoperative nausea and vomiting in women who have had a Caesarean section Injury, Occupational Diseases, Poisoning

Interventions

360 women with no history of obstetric complications or co-morbidity who report at the obstetric unit of the Tamale Teaching Hospital for elective Caesarean section will be recruited for this study, a

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Women undergoing elective Caesarean section

Exclusion criteria

Exclusion criteria: 1. Women undergoing emergency Caesarean section 2. Women who have refused to give consent to the study 3. Any co-morbidity

Design outcomes

Primary

Measure	Time frame
1. Episodes of postoperative nausea and vomiting (PONV) assessed using using a 3-point ordinal scale (0 = none, 1 = nausea, 2 = vomiting) recorded hourly for the first 4 h and then every 4 h for the next 24 h. The incidence of PONV was calculated and categorized as early (0-4 h) or delayed (5-24 h). 2. Rescue antiemetic use up to 24 h after metoclopramide, propofol or saline administration	—

Secondary

Measure	Time frame
1. Episodes of pruritus assessed using a four-point categorical scale (0 = no pruritus, 1 = mild pruritus, 2 = moderate pruritus, 3 = severe pruritus) hourly for the first 4 hours and then 4 hourly for the next 48 hours after surgery 2. Pain intensity assessed using a 100-mm visual analog scale VAS (Mc Cormack et al, 1988), where 0 mm = no pain, and 100 mm = intolerable pain, immediately after surgery 3. Overall perioperative satisfaction evaluated during an interview, where 4 = excellent, 3 = good, 2 = satisfactory, 1 = poor, on the day of hospital discharge	—

Measure

Time frame

1. Episodes of pruritus assessed using a four-point categorical scale (0 = no pruritus, 1 = mild pruritus, 2 = moderate pruritus, 3 = severe pruritus) hourly for the first 4 hours and then 4 hourly for the next 48 hours after surgery 2. Pain intensity assessed using a 100-mm visual analog scale VAS (Mc Cormack et al, 1988), where 0 mm = no pain, and 100 mm = intolerable pain, immediately after surgery 3. Overall perioperative satisfaction evaluated during an interview, where 4 = excellent, 3 = good, 2 = satisfactory, 1 = poor, on the day of hospital discharge

—

Countries

Ghana

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 1, 2026