Knee arthritis Musculoskeletal Diseases Gonoarthrosis
Conditions
Interventions
A package of care will be developed based on current NICE guidelines and on consultation with patients and the public as to the content and delivery of the package of care to ensure it fits well with
will teach them specific exercises that meet their needs
and will explain to them the lifestyle and other changes they can make to improve their knee pain and osteoarthritis and direct them to the appropriate services as required. Over a 3-month period she/
Sponsors
University of Nottingham
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Knee pain on most days of the previous month 2. Pain rated 4-7 on the pain numeric scale (with 0 being no pain and 10 being as bad as it could be) 3. Knee pain present for longer than 3 months 4. Aged 40 or more years
Exclusion criteria
Exclusion criteria: 1. House-bound or care home resident 2. Dementia 3. Dialysis 4. On home oxygen 5. Serious mental illness 6. Inability to communicate in English 7. Unable to give consent 8. Terminal cancer 9. Known diagnosis of autoimmune rheumatic diseases or psoriasis 10. Knee or hip replacement, or on waiting list for knee or hip replacement 11. Asthma or COPD requiring regular daily oral corticosteroids 12. Unstable angina or heart failure 13. Known peripheral vascular disease 14. Pregnant
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Osteoarthritis symptoms measured using the WOMAC score at 26 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Collected at baseline, week 1, week 13, week 26 visits, and follow-up unless noted otherwise: 1.1. WOMAC (Osteoarthritis symptoms) 1.2. SF-36 V2 (General Health) 1.3. EQ-5D-5L (Quality of life) 1.4. HADS (Anxiety and depression) 1.5. International Physical Activity Questionnaire (IPAQ) 1.6 A service-use questionnaire (SUQ) developed for this study will assess use of NHS or private healthcare, prescription and over-the-counter medicines related to knee pain outside of the study at week 1, week 13, week 26 visits 1.7. Pittsburgh Rehabilitation Participation Scale (PRPS) (week 13 and 26 only) 1.8. Adherence to Exercise Scale for Older Patients (AESOP) (week 13 and 26 only) 2. Clinical and radiological research assessments will include: 2.1. Bilateral tibio-femoral and patellofemoral radiographs (week 1 only) 2.2. Timed Up and Go (TUG) test at week 1, week 13, week 26 visits 2.3. 30-second chair stand test (REF) at week 1, week 13, week 26 visits 2.4. Muscle function testing: isometric strength, isokinetic knee extension, peak power output, fatigue – over 20 knee extensions 2.5. Random cholesterol, HbA1c, and CRP at week 1, week 13, week 26 visits 2.6. Quantitative sensory testing (QST): pain pressure threshold, temporal summation, conditioned pain modulation) at week 1, week 13, week 26 visits 3. Acceptability of the intervention Qualitative interviews will be conducted after the intervention with participants from both intervention arms, representing those with low- and high-adherence to the advice using AESOP. These will explore participants’ overall satisfaction with the intervention and the sequence of treatment, perceptions of nurse-led care and previous treatment experience, level of adherence | — |
Countries
England, United Kingdom
Outcome results
None listed