Pediatric brain tumor treated with radiation therapy Cancer
Conditions
Interventions
For this observational study, participants will complete one 7 Tesla MRI scan. From this scan, parameters of brain vasculature, metabolism and white matter diffusion will be obtained. Additionally, a
Sponsors
Princess Máxima Center
Eligibility
Sex/Gender
All
Age
6 Years to 23 Years
Inclusion criteria
Inclusion criteria: 1. Age between 6 - 23 years old 2. Have been treated for a posterior fossa brain tumor with surgery/chemotherapy only, focal proton RT, or cranial-spinal proton RT 3. At least 6 months and up to 5 years after diagnosis, and completed treatment 4. Able to complete MRI without anesthesia
Exclusion criteria
Exclusion criteria: 1. No signed informed consent (either by patient and/or parents/legal guardian) 2. Insufficient knowledge of the Dutch language to perform the neuropsychological assessment or complete questionnaires 3. Significant visual, motor, or developmental problems and thus alternative neuropsychological assessments would be needed (e.g., blindness, deafness, profound developmental delay) 4. MRI-specific exclusion criteria, such as metal implants. Screening for MRI specific exclusion criteria will be done using the typical 7-Tesla MRI safety screening.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measured once: 1. Performance on a sustained attention task (K-CPT-2/CPT-3 measure) 2. 7T MRI metrics measuring vascular health, metabolism, and diffusion in the brain measured using MRI processing | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Neuropsychological measures: 1.1 Estimated IQ measured using the Vocabulary and Matrix Reasoning subtests from WISC-V/WAIS-IV at 1-5 years after diagnosis 1.2 Working memory measured using the Digit Span, Picture Span and/or Arithmetic subtests from WISC-V/WAIS-IV at 1-5 years after diagnosis 1.3. Processing speed measured using the Coding and Symbol Search subtests from WISC-V/WAIS-IV at 1-5 years after diagnosis 1.4. Executive functioning measured using the subtests Road Walking and Word Naming from IDS-2 at 1-5 years after diagnosis 1.5. Memory measured using RAVLT at 1-5 years after diagnosis 1.6. Visual-motor measured using the Purdue Pegboard at 1-5 years after diagnosis 1.7. Questionnaires filled out by parents and/or patients to measure executive skills (BRIEF-2/BRIEF-A), behavior (SDQ parent/SDQ informant), quality of life (PedsQL Generic), fatigue (PedsQL Fatigue) and pre-morbid medical, psychosocial and school functioning (PAT2.0). All neuropsychological measures are administered at one timepoint at 1-5 years after diagnosis. Parents are asked to complete the questionnaires via a safe, online KLIK portal at this same timepoint 2. Clinical, biological, and psychosocial variables will be identified from the medical record and parent questionnaires. This will include clinical data (e.g., demographic, treatment, RT dose, complications), and premorbid history (e.g., birth, health, school, SES). Scores are either continuous or categorical (yes/no) depending on the metric. | — |
Countries
Netherlands
Outcome results
None listed