Cardiovascular disease associated with obesity Circulatory System Cardiovascular disease
Conditions
Interventions
All participants who express an interest in study participation will be invited to attend Manchester Clinical Research Facility. Following informed consent procedure (estimated to take approximately
Sponsors
The University of Manchester
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patient-participants: 1. Willing and capable to provide consent to participation 2. BMI greater than 30 3. No known ocular diseases 4. No known concurrent clinical problem likely to interfere with participation or completion of the study Healthy controls: 1. BMI lower that 25 2. No known diabetes 3. No known ocular diseases 4. No known concurrent clinical problem likely to interfere with participation or completion of the study
Exclusion criteria
Exclusion criteria: 1. Under 18 years old 2. Intubated/ventilated patients 3. Unwilling to give consent to participation OR advised by consultee that this would be against the patient’s wishes 4. Smoker 5. If eaten with in an hour of the examination 6. If drank alcohol within an hour of the examination 7. If drank coffee within an hour of the examination 8. If overly hungry 9. Recently treated infection 10. Known ocular diseases 11. Known concurrent clinical problem likely to interfere with participation or completion of the study Additional exclusion for healthy controls: 1. Diabetes 2. BMI above 25
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vascular function measured by degree of response to flicker stimulation, retinal arteriolar-venular ratio (AVR) and blood oxygen saturation on the assessment day. | — |
Secondary
| Measure | Time frame |
|---|---|
| Peripheral measurements: blood pressure, pulse wave velocity and blood levels of HbA1c and blood lipids (triglycerides, LDL and HDL cholesterol) on the assessment day. | — |
Countries
United Kingdom
Outcome results
None listed