Viral infection, respiratory tract infections Infections and Infestations
Conditions
Interventions
In this trial, serum samples from healthy volunteers will be collected for analysis. Serum will be collected from subjects that are already planned to visit CHDR for screening or follow-up for a diffe
when the planned screening or follow-up date for the other trial they participate in falls within the study period of this trial, subjects will be asked consent for the additional blood donation. Part
for example, when a scientific question emerges regarding existing immunity, or for the selection of a virus strain for a controlled human infection model. This protocol may be executed multiple times
Sponsors
Centre for Human Drug Research
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18-75 years and in good health; the upper age limit could be lowered for different executions of this protocol, but will never exceed 75 years 2. Good health, based upon the results of medical history 3. Subject has signed informed consent
Exclusion criteria
Exclusion criteria: 1. Evidence of immunodeficiency in medical history 2. Prior use of immunosuppressive medication (systemic glucocorticoids 6 months prior to inclusion or any other systemic immunosuppressive medication at any time), immunoglobulins or systemic antiviral therapy)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assess existing background immunity for respiratory virus stems in the general population using laboratory assessments containing, but not limited to: 1. Hemagglutination inhibiton assay (HAI) titre for selected viral stems, for influenza 2. Microneutralization assay (MN) titre for selected viral stems 3. (Neutralizing) IgG & IgA titre for selected viral stems Serum will be collected from subjects that are already planned to visit CHDR for screening or follow-up for a different study. | — |
Secondary
| Measure | Time frame |
|---|---|
| There are no secondary outcome measures | — |
Countries
Netherlands
Contacts
Public ContactVictor Cnossen
Outcome results
None listed