A comparison of recovery after impacted wisdom tooth removal

Comparison of efficacy of serratiopeptidase and escin after impacted mandibular third molar surgery: a randomized controlled clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN15432618

Enrollment

Registered

2025-11-11

Start date

2024-07-30

Completion date

Unknown

Last updated

2025-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative complications—trismus, facial edema (swelling), and pain—in patients undergoing impacted mandibular third molar (wisdom tooth) extraction. Oral Health

Interventions

This is a triple-blind, split-mouth randomized controlled clinical trial. Each participant undergoes two separate impacted mandibular third molar extractions (one per side) and thus serves as their ow

the operator performs surgery but is blind to evaluation data). Treatments are randomly allocated to sides/orders so that bias is minimized. Outcome measures include postoperative trismus, facial edem

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Medically healthy 2. Presence of two mandibular third molars indicated for surgical extraction 3. No history of pericoronitis or other signs of inflammation within the past 30 days

Exclusion criteria

Exclusion criteria: 1. Current use of other medications such as NSAIDs or corticosteroids 2. Known allergy to any drugs administered in this study 3. Pregnancy or breastfeeding 4. History of diabetes or hypertension 5. Previous irradiation to the maxillofacial region 6. Intellectual disability or inability to attend follow-up visits 7. Presence of acute or subacute pericoronitis

Design outcomes

Primary

Measure	Time frame
The following primary outcome measures were assessed before and after the surgical procedure: 1. Facial edema was measured using a flexible measuring scale while the patient maintained a closed-mouth position 2. Trismus was measured using the change in maximum mouth opening with a calibrated ruler (the distance between the incisal edges of the upper and lower central incisors was measured in millimeters) 3. Pain intensity was measured using a standardized 10-centimeter Visual Analogue Scale (VAS)	—

Measure

Time frame

The following primary outcome measures were assessed before and after the surgical procedure: 1. Facial edema was measured using a flexible measuring scale while the patient maintained a closed-mouth position 2. Trismus was measured using the change in maximum mouth opening with a calibrated ruler (the distance between the incisal edges of the upper and lower central incisors was measured in millimeters) 3. Pain intensity was measured using a standardized 10-centimeter Visual Analogue Scale (VAS)

—

Secondary

Measure	Time frame
There are no secondary outcome measures	—

Countries

Yemen

Contacts

Public ContactArwa Mohammed Hussien Dahak

hamddahak@gmail.com+967 (1) 373237

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026