Comparison of the effectiveness of two different respiratory exercise training methods in prolonged ventilated patients

Comparing effectiveness REspiratory Muscle Dysfunction Interventions IMT versus RMT study in prolonged ventilated patients

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN15425727

Enrollment

Registered

2020-07-05

Start date

2019-09-06

Completion date

Unknown

Last updated

2022-10-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory muscle dysfunction in prolonged ventilated patients Respiratory

Interventions

Participants will either receive: 1. 2 weeks of inspiratory muscle training, or 2. 2 weeks of both expiratory and inspiratory muscle training The same

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Adult patients 18 years or above admitted to general critical care unit and required mechanical ventilation support for more than five days 2. Patients who can respond to the verbal command and can tolerate breathing exercises such as “deep breath in and out” 3. Richmond Agitation-Sedation Scale score 0

Exclusion criteria

Exclusion criteria: 1. Medically unstable during critical care admission and prolonged ventilation period before training 2. Use of more than minimal continuous infusion inotropic agents 3. Contraindication to disconnect the patient from the mechanical ventilator for RMT treatment or IMT treatment 4. Acute coronary artery disease 5. Thoracic contraindications

Design outcomes

Primary

Measure	Time frame
Maximum Inspiratory Pressure (MIP) measured using CE marked Micro RPM (Respiratory Pressure Monitor) at pre-(baseline) and post-intervention (2 weeks). 3 trials are taken and the highest value will be used.	—

Secondary

Measure	Time frame
Measures will be performed pre-(baseline) and post-intervention (2 weeks): 1. Maximum Expiratory Pressure (MEP) will be measured using a pressure manometer - 3 trials are taken and the highest value will be used 2. Cough strength will be measured using a semi-quantitative cough strength score 3. Fatigue resistance index will be measured using the ratio of MIP, post-training with Inspiratory Muscle Trainer/MIP pre-training. 4. Rectus abdominis muscle thickness assessment will be measured using a diagnostic ultrasound machine 5. Hand dynamometry will be measure peripheral muscle function – 3 trials are taken on the participants dominant hand and the highest value will be used	—

Measure

Time frame

Measures will be performed pre-(baseline) and post-intervention (2 weeks): 1. Maximum Expiratory Pressure (MEP) will be measured using a pressure manometer - 3 trials are taken and the highest value will be used 2. Cough strength will be measured using a semi-quantitative cough strength score 3. Fatigue resistance index will be measured using the ratio of MIP, post-training with Inspiratory Muscle Trainer/MIP pre-training. 4. Rectus abdominis muscle thickness assessment will be measured using a diagnostic ultrasound machine 5. Hand dynamometry will be measure peripheral muscle function – 3 trials are taken on the participants dominant hand and the highest value will be used

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Countries

Ireland

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026