Ischemic heart disease severity and surgical outcome after cardiac surgery Circulatory System
Conditions
Interventions
The researchers harvest samples from the right atrial appendage and perform RNA sequencing. After that, they apply bioinformatic analyses and compare RNA-sequenced data to clinical data in order to fi
Sponsors
Helsinki University Central Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients undergoing CABG or aortic valve surgery
Exclusion criteria
Exclusion criteria: No surgical intervention
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differentially expressed genes in right atrial appendage tissue among patient groups, measured using Trimmomatic, EnsEMBL gene collection v82 and R bioconductor’s package edgeR after RNA sequencing after surgery. RNA sequencing data is compared to clinical data from the preoperative period and the 3-month control visit using Pearson R, Mann-Whitney U-test, Student’s t-test. | — |
Secondary
| Measure | Time frame |
|---|---|
| Differentially expressed miRNAs in right atrial appendage tissue among patient groups, measured using Trimmomatic, EnsEMBL gene collection v82 and R bioconductor’s package edgeR after RNA sequencing at after surgery. miRNA data is compared to clinical data from the preoperative period and the 3-month control visit using Pearson R, Mann-Whitney U-test, Student’s t-test. | — |
Countries
Finland
Contacts
Public ContactEsko Kankuri
Outcome results
None listed