Evaluate - can magnetic resonance imaging (MRI) pick up early tumour spread in pancreatic cancer?

Evaluation of multi-parametric magnetic resonance imaging for characterising lymph node status, peritoneal and liver metastasis in pancreatic cancer

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN15395684

Enrollment

Registered

2017-11-29

Start date

2016-09-01

Completion date

Unknown

Last updated

2018-07-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pancreatic cancer Cancer Malignant neoplasm of pancreas

Interventions

All patients will attend the CRIC for a a multi-parametric MRI scan roughly 2 weeks before their surgery (index test)

the MRI scan will not be reported and the images will not be made available to the care team. During surgery (usual care), a visual examination, intraoperative ultrasound and/or frozen section intraop

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patient = 18 years 2. Confirmed or suspected pancreatic cancer referred for pancreaticoduodenectomy 3. Fit for general anaesthesia 4. Signed informed consent

Exclusion criteria

Exclusion criteria: 1. Prisoners and adults lacking capacity to consent 2. Patients undergoing distal or total pancreatectomy 3. Contraindications to MR (implanted electronic devices, metallic foreign bodies, claustrophobia, body weight >140 kg or waist perimeter exceeding manufacturer‘s recommendations and others according to manufacturer’s recommendations and generally accepted guidelines)

Design outcomes

Primary

Measure	Time frame
Proportion of patients correctly identified by MRI as being ‘resectable’ (no lymph node, peritoneal or liver metastases) as determined by sensitivity and positive predictive values (PPV). Data collected at surgery (whether resection for pancreatic cancer goes ahead or not) and the preoperative MRI scan (whether metastases are identified or not).	—

Secondary

Measure	Time frame
Data collected at surgery and the preoperative MRI scan: 1. Proportion of patients correctly identified by MRI to have lymph node, peritoneal or liver metastases. Position of ‘pathological’ lymph nodes on MRI is correlated with the final histology 2. Intra- and inter-observer reliability of MRI 3. Optimal combination of MRI parameters to detect metastasis 4. Safety of MRI in this patient population 5. Feasibility parameters (recruitment) 6. Resource use and costs for a preliminary economic evaluation, collected during the patient’s hospital stay 7. Vital status of participants for 5 years after the last patient is recruited	—

Measure

Time frame

Data collected at surgery and the preoperative MRI scan: 1. Proportion of patients correctly identified by MRI to have lymph node, peritoneal or liver metastases. Position of ‘pathological’ lymph nodes on MRI is correlated with the final histology 2. Intra- and inter-observer reliability of MRI 3. Optimal combination of MRI parameters to detect metastasis 4. Safety of MRI in this patient population 5. Feasibility parameters (recruitment) 6. Resource use and costs for a preliminary economic evaluation, collected during the patient’s hospital stay 7. Vital status of participants for 5 years after the last patient is recruited

—

Countries

United Kingdom

Contacts

Public ContactJonathan Evans

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 26, 2026